Canine Distemper
Canine distemper virus
Også kendt som: CDV Infection, Canine Distemper Virus Infection, Hard pad disease
Kort sagt
Canine distemper is a highly contagious, severe viral disease affecting dogs and ferrets. It attacks multiple body systems, including the respiratory, gastrointestinal, and nervous systems, often leading to irreversible neurological damage. Understanding its signs, diagnostic process, and the critical importance of vaccination is essential for every pet owner.

TL;DR. Meget smitsom, livstruende virusinfektion hos hund og ilder med skade på luftveje, mave-tarm og nervesystem; ofte permanente neurologiske følger.
Alvorlig systemisk sygdom med udtalt letargi.
Hvad er det?
Morbillivirus (CDV). Rammer lymfoidt, nerve- og epitelvæv. Faser: lymfopeni/feber, derefter luftveje/GI/hud/øjne, ofte CNS. Intet kurativt antiviral.
Årsager og risikofaktorer
Aerosol og kropsvæsker.
"CDV is shed in respiratory secretions for up to 90 days after infection. Initial replication of CDV is in lymphoid tissue, and viral destruction of lymphocytes results in lymphopenia and pyrexia."
Uvaccinerede hvalpe 6-12 uger højeste risiko; ildere næsten 100% dødeligt. Ingen raceprædisposition.
Tegn
- Myoklonus (kardinal)
- Almindelige: feber, depression, mukopurulent næseflåd, hoste, opkast/diarré, pustler, hyperkeratose (hard pad), kramper, ataksi
- Lejlighedsvis: uveitis, optikusneuritis, KCS, emaljehypoplasi

Hyperkeratose af trædepuder er klassisk.
Diagnostik
CBC (lymfopeni), thoraxrøntgen, konjunktivalcytologi, RT-PCR (guldstandard), IHC, evt. CSF.

Thoraxrøntgen vurderer sekundær pneumoni.
Behandling
Kun støttende: IV-væske, antibiotika mod sekundærinfektion, respirationsstøtte, antiemetika, antikonvulsiva. Glucocorticoids selektivt. Streng isolation.
Prognose
Ofte dårlig, især ved CNS-tegn.
"CNS disease is generally progressive and carries a poor prognosis; it can develop in some dogs that never had systemic signs of disease recognized."
Forebyggelse
Core-vaccine hvalpe + boostere; ilder-specifik vaccine; karantæne; desinfektion.
Hvornår ringe til dyrlæge
Akut: kramper/myoklonus; alvorlig åndenød; gulgrønt flåd; kollaps; alvorlige GI-tegn; pludselig blindhed.
Kilder
- Textbook of Veterinary Internal Medicine, 5th Edition, pages 1077, 1375
- Small Animal Critical Care Medicine, 2nd Edition, page 561
My highlights & notes
Tegn og symptomer
Hvordan det diagnosticeres
- Cerebrospinal fluid (CSF) analysis
- Complete Blood Count (CBC)
- Cytologic examination of conjunctival scrapings
- Immunohistochemistry (IHC) on biopsies
- Reverse transcriptase-polymerase chain reaction (RT-PCR)
- Thoracic radiography
Behandlingsmetoder
Behandling skal ordineres af en autoriseret dyrlæge. Specifikke doser vises bevidst ikke.
Ofte stillede spørgsmål
What is Canine Distemper?
Canine distemper is a highly contagious, severe viral disease affecting dogs and ferrets. It attacks multiple body systems, including the respiratory, gastrointestinal, and nervous systems, often leading to irreversible neurological damage. Understanding its signs, diagnostic process, and the critical importance of vaccination is essential for every pet owner.
What are the symptoms of Canine Distemper?
Myoclonus、Loss of appetite、Ataxia (wobbly, unsteady walking)、Low mood and dullness、Diarrhoea、Enamel hypoplasia、Fever、Hyperkeratosis of the nose and footpads
How is Canine Distemper diagnosed?
Cerebrospinal fluid (CSF) analysis、Complete Blood Count (CBC)、Cytologic examination of conjunctival scrapings、Immunohistochemistry (IHC) on biopsies、Reverse transcriptase-polymerase chain reaction (RT-PCR)、Thoracic radiography
How is Canine Distemper treated?
Behandling skal ordineres af en autoriseret dyrlæge. Specifikke doser vises bevidst ikke.
Kilder
- Internal Medicine 5th · p. 1375
- Internal Medicine 5th · p. 1375
- Internal Medicine 5th · p. 1077
- Small Animal Critical Care Medicine, 2nd Edition (VetBooks.ir) · p. 561
- Small Animal Critical Care Medicine, 2nd Edition (VetBooks.ir) · p. 561
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