Chlorambucil
別名: Leukeran, Chloraminophene, Linfolysin
### Important Information for Pet Owners * **Administration:** Give this medication exactly as directed by your veterinarian. Do not change the dose or stop abruptly without consulting your vet. * **Safe Handling:** Because this is a chemotherapy drug, **wear gloves** when handling the tablets or suspension. Wash your hands thoroughly afterward. Pregnant women should avoid handling this medication entirely. * **What to Watch For:** Immediately report any signs of toxicity to your veterinarian. This includes abnormal bleeding, unexplained bruising, blood in urine or stool, severe lethargy, signs of infection (like fever), or shortness of breath. * **Monitoring:** Your pet will need regular blood tests to ensure the drug is not suppressing their bone marrow too much.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Adjunctive therapy for glomerulonephritis
- Canine lymphoma (first level treatment when combination chemo is declined)
- Lymphoproliferative disease; macroglobulinemia
- Pemphigus complex
- Pemphigus complex
- Adjunctive treatment of inflammatory bowel disease
- Chronic lymphocytic leukaemia
- Lymphoma
- Pemphigus complex
- Protein-losing enteropathy and other immune-mediated diseases
- Metronomic chemotherapy
- Refractory or severe IBD (Cats > 4 kg)
- Refractory or severe IBD (Cats < 4 kg)
給藥方式
可能的副作用
- Myelosuppression (anemia, leukopenia, thrombocytopenia)
- Gastrointestinal toxicity (vomiting, diarrhea)
- Alopecia and delayed hair regrowth (especially in Poodles and Kerry Blue Terriers)
- Neurotoxicity (rare; facial twitching, myoclonus, agitation, seizures)
注意事項與禁忌
- Known hypersensitivity or resistance to the drug
- Pregnancy (potential teratogen)
- > **Important Warnings:** * **Myelosuppression:** Use with extreme caution in patients with preexisting bone marrow depression or active infections. * **Toxicity:** Higher dosages increase the likelihood of toxicity. Nadirs usually occur within 7-14 days of starting therapy. * **Reproductive Safety:** Potential teratogen. Avoid during pregnancy unless benefits clearly outweigh risks. Documented to cause irreversible infertility in male humans. * **Handling:** Caregivers should wear gloves when handling this medication to prevent accidental exposure.
藥物相互作用
- Chloramphenicol: Additive bone marrow depression
- Flucytosine: Additive bone marrow depression
- Amphotericin B: Additive bone marrow depression
- Colchicine: Additive bone marrow depression
- Azathioprine: Increased risk of infection and immunosuppression
- Cyclophosphamide: Increased risk of infection and immunosuppression
- Cyclosporine: Increased risk of infection and immunosuppression
- Corticosteroids: Increased risk of infection and immunosuppression
- Hepatic cytochrome P450 stimulators: Increases cytotoxic effects of chlorambucil
- Prednisolone: Synergistic effect in the management of lymphoid neoplasia
常見問題
Chlorambucil用於寵物有甚麼用途？
### Important Information for Pet Owners * **Administration:** Give this medication exactly as directed by your veterinarian. Do not change the dose or stop abruptly without consulting your vet. * **Safe Handling:** Because this is a chemotherapy drug, **wear gloves** when handling the tablets or suspension. Wash your hands thoroughly afterward. Pregnant women should avoid handling this medication entirely. * **What to Watch For:** Immediately report any signs of toxicity to your veterinarian. This includes abnormal bleeding, unexplained bruising, blood in urine or stool, severe lethargy, signs of infection (like fever), or shortness of breath. * **Monitoring:** Your pet will need regular blood tests to ensure the drug is not suppressing their bone marrow too much.
Chlorambucil對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。