苯丁酸氮芥
別名: Leukeran, Chloraminophene, Linfolysin
藥物類別: Immunosuppressant / Antineoplastic
### 寵物主人重要須知 * **給藥方式：** 請嚴格按照獸醫的指示給藥。未經獸醫同意，請勿自行更改劑量或突然停藥。 * **安全操作：** 由於這是一種化療藥物，處理藥片或懸浮液時請**戴上手套**。處理後請徹底洗手。孕婦應完全避免接觸此藥物。 * **注意事項：** 如果發現任何毒性跡象，請立即向獸醫報告。這包括異常出血、不明原因的瘀傷、尿液或糞便帶血、嚴重嗜睡、感染跡象（如發燒）或呼吸急促。 * **監測：** 您的寵物需要定期進行血液檢查，以確保藥物不會過度抑制其骨髓功能。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Adjunctive therapy for glomerulonephritis
- Canine lymphoma (first level treatment when combination chemo is declined)
- Lymphoproliferative disease; macroglobulinemia
- Pemphigus complex
- Pemphigus complex
- Adjunctive treatment of inflammatory bowel disease
- Chronic lymphocytic leukaemia
- Lymphoma
- Pemphigus complex
- Protein-losing enteropathy and other immune-mediated diseases
- Metronomic chemotherapy
- Refractory or severe IBD (Cats > 4 kg)
- Refractory or severe IBD (Cats < 4 kg)
給藥方式
PO
可能的副作用
- Myelosuppression (anemia, leukopenia, thrombocytopenia)
- Gastrointestinal toxicity (vomiting, diarrhea)
- Alopecia and delayed hair regrowth (especially in Poodles and Kerry Blue Terriers)
- Neurotoxicity (rare; facial twitching, myoclonus, agitation, seizures)
注意事項與禁忌
- Known hypersensitivity or resistance to the drug
- Pregnancy (potential teratogen)
- > **Important Warnings:** * **Myelosuppression:** Use with extreme caution in patients with preexisting bone marrow depression or active infections. * **Toxicity:** Higher dosages increase the likelihood of toxicity. Nadirs usually occur within 7-14 days of starting therapy. * **Reproductive Safety:** Potential teratogen. Avoid during pregnancy unless benefits clearly outweigh risks. Documented to cause irreversible infertility in male humans. * **Handling:** Caregivers should wear gloves when handling this medication to prevent accidental exposure.
藥物相互作用
- Chloramphenicol: Additive bone marrow depression
- Flucytosine: Additive bone marrow depression
- Amphotericin B: Additive bone marrow depression
- Colchicine: Additive bone marrow depression
- Azathioprine: Increased risk of infection and immunosuppression
- Cyclophosphamide: Increased risk of infection and immunosuppression
- Cyclosporine: Increased risk of infection and immunosuppression
- Corticosteroids: Increased risk of infection and immunosuppression
- Hepatic cytochrome P450 stimulators: Increases cytotoxic effects of chlorambucil
- Prednisolone: Synergistic effect in the management of lymphoid neoplasia
常見問題
苯丁酸氮芥用於寵物有什麼用途？
### 寵物主人重要須知 * **給藥方式：** 請嚴格按照獸醫的指示給藥。未經獸醫同意，請勿自行更改劑量或突然停藥。 * **安全操作：** 由於這是一種化療藥物，處理藥片或懸浮液時請**戴上手套**。處理後請徹底洗手。孕婦應完全避免接觸此藥物。 * **注意事項：** 如果發現任何毒性跡象，請立即向獸醫報告。這包括異常出血、不明原因的瘀傷、尿液或糞便帶血、嚴重嗜睡、感染跡象（如發燒）或呼吸急促。 * **監測：** 您的寵物需要定期進行血液檢查，以確保藥物不會過度抑制其骨髓功能。
苯丁酸氮芥對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。