Addison Disease
Hypoadrenocorticism
Juga dikenal sebagai: Hypoadrenocorticism, Addison's disease, Adrenal insufficiency
Singkatnya
Addison's disease is an uncommon endocrine disorder where the adrenal glands fail to produce vital hormones. This leads to severe gastrointestinal issues, weakness, and life-threatening electrolyte imbalances. While an Addisonian crisis is a veterinary emergency, the long-term prognosis is excellent with lifelong daily or monthly hormone replacement therapy.
TL;DR. Gagal adrenal serius tapi sangat dapat diobati; obat seumur hidup memberi kualitas hidup unggul.
Kelenjar adrenal di depan ginjal menghasilkan kortisol dan aldosteron.
Apa itu?
Gluko- dan mineralokortikoid rendah. Terutama anjing; jarang pada kucing. Tanpa aldosteron: hiperkalemia, hiponatremia, hipovolemia, bradikardia, syok.
Penyebab dan faktor risiko
Sering destruksi korteks imun. Juga iatrogenik setelah stop steroid mendadak atau overtreatment Cushing. Predisposisi ras pada beberapa anjing.
Tanda yang perlu diperhatikan
- Lesu, anoreksia, muntah/diare, kelemahan (umum)
- Dehidrasi; bradikardia (kadang)
- Kolaps / syok hipovolemik (krisis Addison)
Lesu dan lemah adalah tanda awal yang umum.
Diagnosis
Rasio Na:K, hiperkalemia. Tes stimulasi ACTH (baku emas). EKG jika aritmia K.
EKG mendeteksi aritmia berbahaya dari kalium tinggi.
Pengobatan
Krisis: cairan i.v. agresif, Dexamethasone. Pemeliharaan: DOCP atau Fludrocortisone plus prednison; dosis stres.
Prognosis
Sangat baik dengan terapi stabil seumur hidup.
Pencegahan
Jangan hentikan steroid secara mendadak. Skrining breeding jika predisposisi.
Kapan menghubungi dokter hewan
Darurat: kolaps, kelemahan ekstrem, diare/muntah berdarah, gusi pucat.
Sumber
- Textbook of Veterinary Internal Medicine, 5th Edition, page 884, 888.
- Small Animal Critical Care Medicine, 2nd Edition, pages 425, 427.
My highlights & notes
Tanda & gejala
Ras berisiko lebih tinggi
Cara didiagnosis
- ACTH Stimulation TestStandar emas
- Abdominal Ultrasonography
- Baseline endogenous ACTH concentration
- Electrocardiogram (ECG)
- Low-dose ACTH stimulation test
- Plasma aldosterone concentrations during ACTH stimulation test
- Radiography
- Serum electrolyte concentrations (Na:K ratio)
Pendekatan pengobatan
Pengobatan harus diresepkan dokter hewan berlisensi. Dosis spesifik sengaja tidak ditampilkan.
Pertanyaan umum
What is Addison Disease?
Addison's disease is an uncommon endocrine disorder where the adrenal glands fail to produce vital hormones. This leads to severe gastrointestinal issues, weakness, and life-threatening electrolyte imbalances. While an Addisonian crisis is a veterinary emergency, the long-term prognosis is excellent with lifelong daily or monthly hormone replacement therapy.
What are the symptoms of Addison Disease?
Loss of appetite、Dehydration、Diarrhoea、Lethargy、Vomiting (throwing up)、Weakness (low energy, no strength)、Weight loss (getting thinner)、Hematemesis
How is Addison Disease diagnosed?
ACTH Stimulation Test、Abdominal Ultrasonography、Baseline endogenous ACTH concentration、Electrocardiogram (ECG)、Low-dose ACTH stimulation test、Plasma aldosterone concentrations during ACTH stimulation test
How is Addison Disease treated?
Pengobatan harus diresepkan dokter hewan berlisensi. Dosis spesifik sengaja tidak ditampilkan.
Sumber
- Internal Medicine 5th · p. 884
- Small Animal Critical Care Medicine, 2nd Edition (VetBooks.ir) · p. 425
- Internal Medicine 5th · p. 884
- Small Animal Critical Care Medicine, 2nd Edition (VetBooks.ir) · p. 427
- Internal Medicine 5th · p. 888
- Internal Medicine 5th · p. 888
Artikel ini edukasi umum, bukan pengganti saran dokter hewan. Jika hewan sakit, konsultasikan dokter hewan.
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