Dilated cardiomyopathy or advanced atrioventricular valve insufficiency
Starting dose for normal cats weighing less than 3 kg
Starting dose for normal cats weighing 3 to 6 kg
Starting dose for normal cats weighing more than 6 kg
Management of supraventricular tachyarrhythmias
Management of supraventricular tachyarrhythmias (Emergency/Rare)
Dilated cardiomyopathy
Maintenance
Dilated cardiomyopathy long-term maintenance
Loading dose
Maintenance Dose
Emergency stabilization
Dilated cardiomyopathy in Hamsters
給藥方式
POIV
可能的副作用
Cardiac arrhythmias (complete or incomplete heart block, bigeminy, ST segment changes, paroxysmal ventricular or atrial tachycardias, multifocal VPCs)
Mild GI upset
Anorexia
Weight loss
Diarrhea
Vomiting (especially associated with IV injections)
Vomiting
Diarrhoea
Depression
Arrhythmias (AV block, bigeminy, paroxysmal ventricular or atrial tachycardias with block, multiform VPCs)
Vasoconstriction (with IV administration)
注意事項與禁忌
Ventricular fibrillation
Digitalis intoxication
Hypertrophic cardiomyopathy in cats (relative contraindication, may increase myocardial oxygen demand and dynamic outflow obstruction)
Frequent ventricular arrhythmias
Atrioventricular (AV) block
Feline hypertrophic cardiomyopathy
Hypokalaemia
> **Extreme Caution:** Patients with glomerulonephritis and heart failure, or with idiopathic hypertrophic subaortic stenosis (IHSS).
* **Caution:** Severe pulmonary disease, hypoxia, acute myocarditis, myxedema, acute myocardial infarction, frequent VPCs, V-tach, chronic constrictive pericarditis, or incomplete AV block.
* **Renal Disease:** Principally eliminated by the kidneys; use with caution and monitor serum levels closely in patients with renal impairment.
* **Electrolyte/Endocrine Imbalances:** Animals that are hypernatremic, hypokalemic, hypercalcemic, hyper- or hypothyroid may require smaller dosages; monitor carefully.
* **Cardioversion:** Elective cardioversion of patients with atrial fibrillation should be postponed until digoxin has been withheld for 1-2 days.
* **Dosing Weight:** Dosing is generally based upon **lean body weight** as digoxin does not distribute well into ascitic fluid or fat.
藥物相互作用
Aminosalicylic Acid: May reduce digoxin serum levels
Antacids: May reduce digoxin serum levels
Chloramphenicol: May reduce digoxin serum levels in dogs
Cholestyramine: May reduce digoxin serum levels
Cimetidine: May reduce digoxin serum levels
Metoclopramide: May reduce digoxin serum levels
Neomycin (Oral): May reduce digoxin serum levels
Phenobarbital: May reduce digoxin serum levels
St John's Wort: May reduce digoxin serum levels
Sucralfate: May reduce digoxin serum levels
Sulfasalazine: May reduce digoxin serum levels
Amiodarone: May increase serum levels, decrease elimination rate, or enhance toxic effects
