Digoxin
別名: Lanoxin, Cardoxin, Lanoxin PG
Digoxin is a potent heart medication used to help the heart pump more effectively and control irregular heartbeats. * **Strict Dosing:** Give this medication exactly as prescribed. Do not change the dose or stop the medication without consulting your veterinarian, as the difference between a helpful dose and a toxic dose is very small. * **Watch for Toxicity:** Contact your veterinarian immediately if your pet shows any signs of toxicity, which often start with gastrointestinal upset. Watch for **loss of appetite, vomiting, diarrhea, lethargy, depression, or changes in behavior**. * **Missed Doses:** If you miss a dose, do not double up on the next dose. Give the next dose at the regularly scheduled time. * **Monitoring:** Your pet will need regular blood tests to check the level of digoxin in their blood, as well as kidney function and electrolyte levels, to ensure the dose remains safe and effective.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Dilated cardiomyopathy or advanced atrioventricular valve insufficiency
- Starting dose for normal cats weighing less than 3 kg
- Starting dose for normal cats weighing 3 to 6 kg
- Starting dose for normal cats weighing more than 6 kg
- Management of supraventricular tachyarrhythmias
- Management of supraventricular tachyarrhythmias (Emergency/Rare)
- Dilated cardiomyopathy
- Maintenance
- Dilated cardiomyopathy long-term maintenance
- Loading dose
- Maintenance Dose
- Emergency stabilization
- Dilated cardiomyopathy in Hamsters
給藥方式
可能的副作用
- Cardiac arrhythmias (complete or incomplete heart block, bigeminy, ST segment changes, paroxysmal ventricular or atrial tachycardias, multifocal VPCs)
- Mild GI upset
- Anorexia
- Weight loss
- Diarrhea
- Vomiting (especially associated with IV injections)
- Vomiting
- Diarrhoea
- Depression
- Arrhythmias (AV block, bigeminy, paroxysmal ventricular or atrial tachycardias with block, multiform VPCs)
- Vasoconstriction (with IV administration)
注意事項與禁忌
- Ventricular fibrillation
- Digitalis intoxication
- Hypertrophic cardiomyopathy in cats (relative contraindication, may increase myocardial oxygen demand and dynamic outflow obstruction)
- Frequent ventricular arrhythmias
- Atrioventricular (AV) block
- Feline hypertrophic cardiomyopathy
- Hypokalaemia
- > **Extreme Caution:** Patients with glomerulonephritis and heart failure, or with idiopathic hypertrophic subaortic stenosis (IHSS). * **Caution:** Severe pulmonary disease, hypoxia, acute myocarditis, myxedema, acute myocardial infarction, frequent VPCs, V-tach, chronic constrictive pericarditis, or incomplete AV block. * **Renal Disease:** Principally eliminated by the kidneys; use with caution and monitor serum levels closely in patients with renal impairment. * **Electrolyte/Endocrine Imbalances:** Animals that are hypernatremic, hypokalemic, hypercalcemic, hyper- or hypothyroid may require smaller dosages; monitor carefully. * **Cardioversion:** Elective cardioversion of patients with atrial fibrillation should be postponed until digoxin has been withheld for 1-2 days. * **Dosing Weight:** Dosing is generally based upon **lean body weight** as digoxin does not distribute well into ascitic fluid or fat.
藥物相互作用
- Aminosalicylic Acid: May reduce digoxin serum levels
- Antacids: May reduce digoxin serum levels
- Chloramphenicol: May reduce digoxin serum levels in dogs
- Cholestyramine: May reduce digoxin serum levels
- Cimetidine: May reduce digoxin serum levels
- Metoclopramide: May reduce digoxin serum levels
- Neomycin (Oral): May reduce digoxin serum levels
- Phenobarbital: May reduce digoxin serum levels
- St John's Wort: May reduce digoxin serum levels
- Sucralfate: May reduce digoxin serum levels
- Sulfasalazine: May reduce digoxin serum levels
- Amiodarone: May increase serum levels, decrease elimination rate, or enhance toxic effects
常見問題
Digoxin用於寵物有甚麼用途？
Digoxin is a potent heart medication used to help the heart pump more effectively and control irregular heartbeats. * **Strict Dosing:** Give this medication exactly as prescribed. Do not change the dose or stop the medication without consulting your veterinarian, as the difference between a helpful dose and a toxic dose is very small. * **Watch for Toxicity:** Contact your veterinarian immediately if your pet shows any signs of toxicity, which often start with gastrointestinal upset. Watch for **loss of appetite, vomiting, diarrhea, lethargy, depression, or changes in behavior**. * **Missed Doses:** If you miss a dose, do not double up on the next dose. Give the next dose at the regularly scheduled time. * **Monitoring:** Your pet will need regular blood tests to check the level of digoxin in their blood, as well as kidney function and electrolyte levels, to ensure the dose remains safe and effective.
Digoxin對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。