디고신

용도

• Dilated cardiomyopathy or advanced atrioventricular valve insufficiency
• Starting dose for normal cats weighing less than 3 kg
• Starting dose for normal cats weighing 3 to 6 kg
• Starting dose for normal cats weighing more than 6 kg
• Management of supraventricular tachyarrhythmias
• Management of supraventricular tachyarrhythmias (Emergency/Rare)
• Dilated cardiomyopathy
• Maintenance
• Dilated cardiomyopathy long-term maintenance
• Loading dose
• Maintenance Dose
• Emergency stabilization
• Dilated cardiomyopathy in Hamsters

투여 방법

가능한 부작용

• Cardiac arrhythmias (complete or incomplete heart block, bigeminy, ST segment changes, paroxysmal ventricular or atrial tachycardias, multifocal VPCs)
• Mild GI upset
• Anorexia
• Weight loss
• Diarrhea
• Vomiting (especially associated with IV injections)
• Vomiting
• Diarrhoea
• Depression
• Arrhythmias (AV block, bigeminy, paroxysmal ventricular or atrial tachycardias with block, multiform VPCs)
• Vasoconstriction (with IV administration)

주의사항 및 금기

• Ventricular fibrillation
• Digitalis intoxication
• Hypertrophic cardiomyopathy in cats (relative contraindication, may increase myocardial oxygen demand and dynamic outflow obstruction)
• Frequent ventricular arrhythmias
• Atrioventricular (AV) block
• Feline hypertrophic cardiomyopathy
• Hypokalaemia
• > **Extreme Caution:** Patients with glomerulonephritis and heart failure, or with idiopathic hypertrophic subaortic stenosis (IHSS). * **Caution:** Severe pulmonary disease, hypoxia, acute myocarditis, myxedema, acute myocardial infarction, frequent VPCs, V-tach, chronic constrictive pericarditis, or incomplete AV block. * **Renal Disease:** Principally eliminated by the kidneys; use with caution and monitor serum levels closely in patients with renal impairment. * **Electrolyte/Endocrine Imbalances:** Animals that are hypernatremic, hypokalemic, hypercalcemic, hyper- or hypothyroid may require smaller dosages; monitor carefully. * **Cardioversion:** Elective cardioversion of patients with atrial fibrillation should be postponed until digoxin has been withheld for 1-2 days. * **Dosing Weight:** Dosing is generally based upon **lean body weight** as digoxin does not distribute well into ascitic fluid or fat.

약물 상호작용

• Aminosalicylic Acid: May reduce digoxin serum levels
• Antacids: May reduce digoxin serum levels
• Chloramphenicol: May reduce digoxin serum levels in dogs
• Cholestyramine: May reduce digoxin serum levels
• Cimetidine: May reduce digoxin serum levels
• Metoclopramide: May reduce digoxin serum levels
• Neomycin (Oral): May reduce digoxin serum levels
• Phenobarbital: May reduce digoxin serum levels
• St John's Wort: May reduce digoxin serum levels
• Sucralfate: May reduce digoxin serum levels
• Sulfasalazine: May reduce digoxin serum levels
• Amiodarone: May increase serum levels, decrease elimination rate, or enhance toxic effects

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