ブプレノルフィン

使用用途

• Analgesia
• Analgesia
• Analgesia
• Analgesia
• Analgesia
• Analgesia
• Analgesia
• Analgesia
• Analgesia
• Analgesia
• Analgesia in the emergent patient
• Analgesia
• Neuroleptanalgesia
• Neuroleptanalgesia
• Analgesia (acute or chronic visceral pain)

投与方法

考えられる副作用

• Respiratory depression (rare but significant)
• Sedation
• Urine retention or difficulty voiding (particularly with high IV or epidural doses)
• Excitement (horses)
• Diminished gut sounds (horses)
• Vomiting (rare in cats)

注意事項と禁忌

• Known hypersensitivity to buprenorphine
• Use with caution in patients with hypothyroidism, severe renal insufficiency, adrenocortical insufficiency (Addison's), and in geriatric or severely debilitated patients. Use cautiously in patients with compromised cardiopulmonary function due to the rare risk of respiratory depression. Extreme caution is required in patients with head trauma, increased CSF pressure, or CNS dysfunction (e.g., coma). Patients with severe hepatic dysfunction may eliminate the drug more slowly. May increase bile duct pressure; use cautiously in biliary tract disease.

薬物相互作用

• Local Anesthetics (mepivacaine, bupivacaine): May be potentiated by concomitant use of buprenorphine
• Anticonvulsants (phenobarbital, phenytoin): May decrease plasma buprenorphine levels
• Benzodiazepines: Case reports of humans developing respiratory/cardiovascular/CNS depression; use with caution
• CNS Depressants (anesthetics, antihistamines, phenothiazines, barbiturates, alcohol): May cause increased CNS or respiratory depression when used with buprenorphine
• Erythromycin: Can increase plasma buprenorphine levels
• Fentanyl (and other pure opiate agonists): Buprenorphine may potentially antagonize some analgesic effects, but may also reverse some sedative and respiratory depressant effects
• Halothane: Potentially can increase buprenorphine effects
• Azole Antifungals (ketoconazole, itraconazole, fluconazole): Can increase plasma buprenorphine levels
• Monoamine Oxidase Inhibitors (selegiline, amitraz): Possible additive effects or increased CNS depression
• Naloxone: May reduce analgesia associated with high dose buprenorphine

よくある質問