Omeprazole
別名: Gastrogard, Prilosec, Ulcergard, Zegerid, Losec
- **Timing is crucial:** Give this medication on an empty stomach, preferably in the morning, about **30 to 60 minutes before a meal**. The drug needs active proton pumps to work, which are stimulated by eating. - **Do not crush or chew:** If using human capsules or tablets, they are specially coated to survive stomach acid. Crushing or chewing them will destroy the medication before it can be absorbed. - If you must open a capsule to give the pellets, mix them gently with a small amount of fruit juice (not water, milk, or saline) and give immediately without crushing the pellets. - Contact your veterinarian if your pet experiences persistent vomiting, diarrhea, or loss of appetite.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Adjunctive treatment of esophagitis or gastric ulcers
- GI ulcer management/prevention
- Adjunctive treatment of uremic gastropathy
- Short-term treatment of gastroenteritis
- Treatment of gastric ulcers
- Foals: Preventative dose
- Foals: Treatment dose
- Treatment or prophylaxis of gastric ulcers in foals
- Foals: Gastric ulcers
- Ulcer management
- GI ulcer management/prevention
- Adjunctive treatment of uremic gastropathy
- Prevent exercise-induced gastritis in racing Alaskan sled dogs
給藥方式
可能的副作用
- GI distress (anorexia, colic, nausea, vomiting, flatulence, diarrhea)
- Hematologic abnormalities (rare)
- Urinary tract infections
- Proteinuria
- CNS disturbances
- Urticaria (rare in horses)
注意事項與禁忌
- Known hypersensitivity to omeprazole
- Use with caution in patients with severe hepatic or renal disease, as the drug's half-life may be prolonged and dosage adjustment may be necessary. Safety during pregnancy is not fully established (FDA Category C); high doses in lab animals showed embryo-lethality. Nursing is discouraged due to potential adverse effects in infants and tumorigenicity seen in rat studies. Chronic very high doses in rats caused enterochromaffin-like cell hyperplasia and gastric carcinoid tumors, though the clinical significance for standard veterinary use (e.g., 4 weeks in dogs, 90 days in horses) is believed to be low.
藥物相互作用
- Benzodiazepines (e.g., diazepam): Omeprazole may potentially alter benzodiazepine metabolism and prolong CNS effects
- Clarithromycin: Increased levels of omeprazole, clarithromycin and 14-hydroxyclarithromycin are possible
- Cyanocobalamin (oral): Omeprazole may decrease oral absorption
- Cyclosporine: Omeprazole may reduce cyclosporine metabolism
- Ketoconazole, Itraconazole, Iron, Ampicillin esters: Omeprazole increases gastric pH, which may decrease the absorption of these drugs that require an acidic environment
- Warfarin: Omeprazole may increase anticoagulant effect
常見問題
Omeprazole用於寵物有甚麼用途？
- **Timing is crucial:** Give this medication on an empty stomach, preferably in the morning, about **30 to 60 minutes before a meal**. The drug needs active proton pumps to work, which are stimulated by eating. - **Do not crush or chew:** If using human capsules or tablets, they are specially coated to survive stomach acid. Crushing or chewing them will destroy the medication before it can be absorbed. - If you must open a capsule to give the pellets, mix them gently with a small amount of fruit juice (not water, milk, or saline) and give immediately without crushing the pellets. - Contact your veterinarian if your pet experiences persistent vomiting, diarrhea, or loss of appetite.
Omeprazole對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。