奧美拉唑
別名: Gastrogard, Prilosec, Ulcergard, Zegerid, Losec
藥物類別: Proton Pump Inhibitor (PPI)
- **給藥時間很關鍵：** 請在空腹時給予此藥物，最好是在早上，**飯前 30 到 60 分鐘**。藥物需要活躍的質子幫浦才能發揮作用，而進食會刺激這些幫浦。 - **請勿壓碎或咀嚼：** 如果使用人類的膠囊或錠劑，它們具有特殊的腸溶衣以抵抗胃酸。壓碎或咀嚼會使藥物在吸收前就被破壞。 - 如果必須打開膠囊餵食顆粒，請將顆粒與少量果汁（不可用水、牛奶或生理食鹽水）輕輕混合後立即餵食，切勿壓碎顆粒。 - 如果您的寵物出現持續嘔吐、腹瀉或食慾不振，請聯繫您的獸醫師。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Adjunctive treatment of esophagitis or gastric ulcers
- GI ulcer management/prevention
- Adjunctive treatment of uremic gastropathy
- Short-term treatment of gastroenteritis
- Treatment of gastric ulcers
- Foals: Preventative dose
- Foals: Treatment dose
- Treatment or prophylaxis of gastric ulcers in foals
- Foals: Gastric ulcers
- Ulcer management
- GI ulcer management/prevention
- Adjunctive treatment of uremic gastropathy
- Prevent exercise-induced gastritis in racing Alaskan sled dogs
- Adjunctive treatment of esophagitis or gastric ulcers
- Gastrinomas or severe esophagitis
- General GI therapeutics
- Esophagitis
- Adjunctive treatment of uremic vomiting
- Helicobacter infection/gastritis
給藥方式
PO
可能的副作用
- GI distress (anorexia, colic, nausea, vomiting, flatulence, diarrhea)
- Hematologic abnormalities (rare)
- Urinary tract infections
- Proteinuria
- CNS disturbances
- Urticaria (rare in horses)
注意事項與禁忌
- Known hypersensitivity to omeprazole
- Use with caution in patients with severe hepatic or renal disease, as the drug's half-life may be prolonged and dosage adjustment may be necessary. Safety during pregnancy is not fully established (FDA Category C); high doses in lab animals showed embryo-lethality. Nursing is discouraged due to potential adverse effects in infants and tumorigenicity seen in rat studies. Chronic very high doses in rats caused enterochromaffin-like cell hyperplasia and gastric carcinoid tumors, though the clinical significance for standard veterinary use (e.g., 4 weeks in dogs, 90 days in horses) is believed to be low.
藥物相互作用
- Benzodiazepines (e.g., diazepam): Omeprazole may potentially alter benzodiazepine metabolism and prolong CNS effects
- Clarithromycin: Increased levels of omeprazole, clarithromycin and 14-hydroxyclarithromycin are possible
- Cyanocobalamin (oral): Omeprazole may decrease oral absorption
- Cyclosporine: Omeprazole may reduce cyclosporine metabolism
- Ketoconazole, Itraconazole, Iron, Ampicillin esters: Omeprazole increases gastric pH, which may decrease the absorption of these drugs that require an acidic environment
- Warfarin: Omeprazole may increase anticoagulant effect
常見問題
奧美拉唑用於寵物有什麼用途？
- 給藥時間很關鍵： 請在空腹時給予此藥物，最好是在早上，飯前 30 到 60 分鐘。藥物需要活躍的質子幫浦才能發揮作用，而進食會刺激這些幫浦。 - 請勿壓碎或咀嚼： 如果使用人類的膠囊或錠劑，它們具有特殊的腸溶衣以抵抗胃酸。壓碎或咀嚼會使藥物在吸收前就被破壞。 - 如果必須打開膠囊餵食顆粒，請將顆粒與少量果汁（不可用水、牛奶或生理食鹽水）輕輕混合後立即餵食，切勿壓碎顆粒。 - 如果您的寵物出現持續嘔吐、腹瀉或食慾不振，請聯繫您的獸醫師。
奧美拉唑對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。