オメプラゾール

使用用途

• Adjunctive treatment of esophagitis or gastric ulcers
• GI ulcer management/prevention
• Adjunctive treatment of uremic gastropathy
• Short-term treatment of gastroenteritis
• Treatment of gastric ulcers
• Foals: Preventative dose
• Foals: Treatment dose
• Treatment or prophylaxis of gastric ulcers in foals
• Foals: Gastric ulcers
• Ulcer management
• GI ulcer management/prevention
• Adjunctive treatment of uremic gastropathy
• Prevent exercise-induced gastritis in racing Alaskan sled dogs

投与方法

考えられる副作用

• GI distress (anorexia, colic, nausea, vomiting, flatulence, diarrhea)
• Hematologic abnormalities (rare)
• Urinary tract infections
• Proteinuria
• CNS disturbances
• Urticaria (rare in horses)

注意事項と禁忌

• Known hypersensitivity to omeprazole
• Use with caution in patients with severe hepatic or renal disease, as the drug's half-life may be prolonged and dosage adjustment may be necessary. Safety during pregnancy is not fully established (FDA Category C); high doses in lab animals showed embryo-lethality. Nursing is discouraged due to potential adverse effects in infants and tumorigenicity seen in rat studies. Chronic very high doses in rats caused enterochromaffin-like cell hyperplasia and gastric carcinoid tumors, though the clinical significance for standard veterinary use (e.g., 4 weeks in dogs, 90 days in horses) is believed to be low.

薬物相互作用

• Benzodiazepines (e.g., diazepam): Omeprazole may potentially alter benzodiazepine metabolism and prolong CNS effects
• Clarithromycin: Increased levels of omeprazole, clarithromycin and 14-hydroxyclarithromycin are possible
• Cyanocobalamin (oral): Omeprazole may decrease oral absorption
• Cyclosporine: Omeprazole may reduce cyclosporine metabolism
• Ketoconazole, Itraconazole, Iron, Ampicillin esters: Omeprazole increases gastric pH, which may decrease the absorption of these drugs that require an acidic environment
• Warfarin: Omeprazole may increase anticoagulant effect

よくある質問