푸로세미드

용도

• As a general diuretic
• For severe acute pulmonary edema (parenteral dosing)
• For heart failure (oral dosing)
• For chronic therapy (CHF)
• In combination with rest, vasodilators and rate-control
• For adjunctive treatment of moderate to severe hypercalcemia
• For acute oliguric renal failure
• For acute oliguric renal failure (fluid replete patients)
• For adjunctive therapy for heart failure
• For adjunctive therapy for heart failure
• For udder edema
• General use
• For adjunctive therapy for congestive heart failure

투여 방법

가능한 부작용

• Fluid and electrolyte abnormalities (hyponatremia, hypokalemia, hypocalcemia, hypomagnesemia)
• Prerenal azotemia (secondary to dehydration)
• Ototoxicity (especially in cats with high-dose IV therapy)
• Gastrointestinal distress
• Hematologic effects (anemia, leukopenia)
• Weakness and restlessness
• Hypokalaemia
• Hypochloraemia
• Hypocalcaemia
• Hypomagnesaemia
• Hyponatraemia
• Dehydration
• Polyuria/polydipsia (PU/PD)
• Prerenal azotaemia

주의사항 및 금기

• Anuria
• Hypersensitivity to furosemide
• Progressive renal disease if increasing azotemia and oliguria occur during therapy
• Seriously depleted electrolytes
• Severe dehydration
• Severe electrolyte depletion
• Hepatic coma
• Dehydration
• Pericardial effusion where cardiac tamponade is confirmed
• Use with caution in patients with pre-existing electrolyte or water balance abnormalities, impaired hepatic function (may precipitate hepatic coma), and diabetes mellitus. Monitor carefully in patients with conditions leading to fluid loss (e.g., vomiting, diarrhea). Patients hypersensitive to sulfonamides may also be hypersensitive to furosemide. Ensure animals have normal food and water intake to prevent imbalances.

약물 상호작용

• ACE INHIBITORS (e.g., enalapril, benazepril): Increased risks for hypotension, particularly in patients who are volume or sodium depleted secondary to diuretics
• AMINOGLYCOSIDES (gentamicin, amikacin, etc.): Increased risk for ototoxicity
• AMPHOTERICIN B: Loop diuretics may increase the risk for nephrotoxicity development; hypokalemia
• CORTICOSTEROIDS: Increased risk for GI ulceration; hypokalemia
• DIGOXIN: Furosemide-induced hypokalemia may increase the potential for digoxin toxicity
• INSULIN: Furosemide may alter insulin requirements
• MUSCLE RELAXANTS, NON-DEPOLARIZING (e.g., atracurium, tubocurarine): Furosemide may prolong neuromuscular blockade
• PROBENECID: Furosemide can reduce uricosuric effects
• SALICYLATES: Loop diuretics can reduce the excretion of salicylates
• SUCCINYLCHOLINE: Furosemide may potentiate effects
• THEOPHYLLINE: Pharmacologic effects of theophylline may be enhanced when used with furosemide

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