Vincristine
別名: Oncovin, Vincasar PFS
Vincristine is a potent chemotherapy drug used to treat cancer and certain immune system disorders. * **Toxicity Risks**: While generally well-tolerated, severe side effects can occur. Contact your veterinarian immediately if your pet shows profound depression, abnormal bleeding or bruising, bloody diarrhea, severe constipation, or difficulty walking (neuropathy). * **Safety Precautions at Home**: The drug and its breakdown products are excreted in your pet's bodily fluids. **Avoid direct contact with your pet's urine, saliva, or feces for up to 7 days after treatment.** Wear gloves when cleaning up waste, and wash your hands thoroughly afterward. * **Missed Doses**: Chemotherapy schedules are very strict. If you miss an appointment, contact your veterinarian immediately to reschedule.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Neoplastic diseases
- Neoplastic diseases (particularly lymphoproliferative disorders)
- Neoplastic diseases
- Neoplastic diseases (usually in combination protocols)
- Transmissible venereal tumor (TVT)
- Adjunctive treatment of immune-mediated thrombocytopenia (IMT)
- Adjunctive treatment of immune-mediated thrombocytopenia (IMT) refractory to prednisone
- Adjunctive treatment of immune-mediated thrombocytopenia (IMT)
- Neoplastic diseases (particularly lymphoproliferative disorders), immune-mediated thrombocytopenia, transmissible venereal tumour
給藥方式
可能的副作用
- Peripheral neuropathy (proprioceptive deficits, spinal hyporeflexia)
- Paralytic ileus and severe constipation
- Mild leukopenia
- Tissue necrosis and sloughing (if extravasated)
- Anorexia, vomiting, diarrhea
- Impaired platelet aggregation
- Increased liver enzymes
- Syndrome of inappropriate ADH secretion (SIADH)
- Jaw pain
- Alopecia
- Stomatitis
- Seizures
- Pulmonary edema (rare, reported in cats)
- Peripheral neuropathy
注意事項與禁忌
- Preexisting neuromuscular disease
- Severe leukopenia
- Uncontrolled infection
- No specific absolute contraindications listed, but requires extreme caution in specific disease states
- > **Extravasation Warning**: Vincristine is a potent vesicant. It must be given strictly IV. Use a different needle for injection than the one used to draw the drug from the vial. If extravasation occurs, stop immediately, apply moderate heat (or ice, depending on protocol), and consider topical DMSO or hyaluronidase injections. * **ABCB1 (MDR1) Mutation**: Herding breeds (e.g., Collies, Australian Shepherds) with this mutation are highly susceptible to severe bone marrow suppression and GI toxicity. Reduce dose by 25-30% in mutant/normal or mutant/mutant dogs. * **Hepatic Impairment**: Extensively metabolized by the liver. Consider a 50% dose reduction if serum bilirubin is > 2 mg/dL. * **Neurotoxicity**: Cats are particularly sensitive to neurotoxicity, which can manifest as paralytic ileus, severe constipation, and reversible axon swelling. * **Handling**: Wear gloves and protective clothing. Wash thoroughly with soap and water if skin exposure occurs. * **Pregnancy**: Potentially teratogenic and embryotoxic (FDA Category D).
藥物相互作用
- Asparaginase: Additive neurotoxicity may occur; less common if asparaginase is administered after vincristine.
- Mitomycin: Severe bronchospasm has occurred in humans receiving mitomycin-C with Vinca alkaloids.
- Amiodarone: Inhibits P-glycoprotein; may increase vincristine toxicity, especially in MDR1/ABCB1 mutant dogs.
- Azole Antifungals (e.g., ketoconazole): Inhibits P-glycoprotein; may increase vincristine toxicity.
- Carvedilol: Inhibits P-glycoprotein; may increase vincristine toxicity.
- Cyclosporine: Inhibits P-glycoprotein; may increase vincristine toxicity.
- Diltiazem: Inhibits P-glycoprotein; may increase vincristine toxicity.
- Erythromycin: Inhibits P-glycoprotein; may increase vincristine toxicity.
- Clarithromycin: Inhibits P-glycoprotein; may increase vincristine toxicity.
- Quinidine: Inhibits P-glycoprotein; may increase vincristine toxicity.
- Spironolactone: Inhibits P-glycoprotein; may increase vincristine toxicity.
常見問題
Vincristine用於寵物有甚麼用途？
Vincristine is a potent chemotherapy drug used to treat cancer and certain immune system disorders. * **Toxicity Risks**: While generally well-tolerated, severe side effects can occur. Contact your veterinarian immediately if your pet shows profound depression, abnormal bleeding or bruising, bloody diarrhea, severe constipation, or difficulty walking (neuropathy). * **Safety Precautions at Home**: The drug and its breakdown products are excreted in your pet's bodily fluids. **Avoid direct contact with your pet's urine, saliva, or feces for up to 7 days after treatment.** Wear gloves when cleaning up waste, and wash your hands thoroughly afterward. * **Missed Doses**: Chemotherapy schedules are very strict. If you miss an appointment, contact your veterinarian immediately to reschedule.
Vincristine對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。