Sulfadiazine/Trimethoprim and Sulfamethoxazole/Trimethoprim
別名: Co-trimoxazole, Tribrissen, Bactrim, Septra, Tucoprim, Uniprim, Di-Biotic, Cotrim, Sulfatrim, Trivetrin, Borgal
**Important Guidance for Pet Owners:** - **Hydration is Crucial:** Ensure your pet has free access to plenty of fresh water at all times while on this medication. Dehydration can lead to drug crystals forming in the kidneys or urine. - **Watch the Eyes (Dogs):** This medication can decrease tear production, leading to a condition called "dry eye" (keratoconjunctivitis sicca). Contact your veterinarian immediately if you notice your dog squinting, rubbing their eyes, redness, or thick yellow/green eye discharge. - **Allergic Reactions:** Doberman Pinschers and some large breed dogs are more prone to allergic reactions. Stop the medication and call your vet if you notice facial swelling, hives, unexplained fever, joint stiffness/limping, or yellowing of the eyes/gums. - **Administration:** Can be given with or without food. If using the liquid oral suspension, **shake it thoroughly** before drawing up each dose. The liquid does not need to be refrigerated. - **Finish the Course:** Always complete the entire prescription as directed by your veterinarian, even if your pet seems completely better, to prevent antibiotic resistance.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- UTI
- UTI, soft tissue infections
- Susceptible infections
- Toxoplasmosis
- Bacterial UTI
- Susceptible infections
- Coccidiosis
- Susceptible infections
- Susceptible infections
- Susceptible infections (Calves)
- Respiratory tract infections
- Susceptible infections (Foals)
- Susceptible infections
- Susceptible infections
給藥方式
可能的副作用
- Dogs: Keratoconjunctivitis sicca (KCS/dry eye - potentially irreversible)
- Dogs: Hypersensitivity reactions (Type 1 anaphylaxis or Type 3 serum sickness, polyarthritis, urticaria, facial swelling)
- Dogs: Acute neutrophilic hepatitis with icterus, idiosyncratic hepatic necrosis
- Dogs: Vomiting, anorexia, diarrhea
- Dogs: Hemolytic anemia, agranulocytosis
- Dogs: Hypothyroidism (with extended therapy)
- Dogs: Crystalluria, hematuria, polyuria, polydipsia
- Cats: Anorexia, crystalluria, hematuria, leukopenias, anemias
- Horses: Transient pruritus (after IV injection), diarrhea, hypersensitivity, hematologic effects
- Injection site reactions: Swelling, pain, tissue damage (IM, SC, or extravasation)
注意事項與禁忌
- Hypersensitivity to sulfonamides, thiazides, or sulfonylurea agents
- Severe renal or hepatic impairment
- Doberman pinschers (highly susceptible to immune complex disease)
- Marked blood dyscrasias
- Animals intended for food (in the USA/certain jurisdictions)
- Use with caution in patients with pre-existing hepatic or renal disease. Because of its potential for crystallization in the urine, avoid use in dogs known to have uroliths, at increased risk for developing uroliths, or those with highly concentrated (dehydrated) or acidic urine. Potentially teratogenic (cleft palate reported); weigh risk vs. benefit in pregnant animals. Use with caution in nursing animals as sulfonamides are excreted in milk and may cause kernicterus in neonates.
藥物相互作用
- Amantadine: May cause toxic delirium (reported in humans)
- Antacids: May decrease the bioavailability of sulfonamides if administered concurrently
- Cyclosporine: May increase the risk of nephrotoxicity
- Digoxin: May increase digoxin levels
- Diuretics, Thiazide: May increase risk for thrombocytopenia
- Hypoglycemic agents, oral: May potentiate hypoglycemic effects
- Methotrexate: May displace from plasma proteins and increase risk for toxic effects; can also interfere with MTX assays
- Phenytoin: May increase half-life of phenytoin
- Tricyclic antidepressants: May decrease efficacy of the antidepressant
- Warfarin: May prolong INR/PT and increase bleeding risk
常見問題
Sulfadiazine/Trimethoprim and Sulfamethoxazole/Trimethoprim用於寵物有甚麼用途？
**Important Guidance for Pet Owners:** - **Hydration is Crucial:** Ensure your pet has free access to plenty of fresh water at all times while on this medication. Dehydration can lead to drug crystals forming in the kidneys or urine. - **Watch the Eyes (Dogs):** This medication can decrease tear production, leading to a condition called "dry eye" (keratoconjunctivitis sicca). Contact your veterinarian immediately if you notice your dog squinting, rubbing their eyes, redness, or thick yellow/green eye discharge. - **Allergic Reactions:** Doberman Pinschers and some large breed dogs are more prone to allergic reactions. Stop the medication and call your vet if you notice facial swelling, hives, unexplained fever, joint stiffness/limping, or yellowing of the eyes/gums. - **Administration:** Can be given with or without food. If using the liquid oral suspension, **shake it thoroughly** before drawing up each dose. The liquid does not need to be refrigerated. - **Finish the Course:** Always complete the entire prescription as directed by your veterinarian, even if your pet seems completely better, to prevent antibiotic resistance.
Sulfadiazine/Trimethoprim and Sulfamethoxazole/Trimethoprim對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。