Pimobendan
別名: Vetmedin, Acardi, Cardisure, Pimocard, Fortekor-Plus
Pimobendan is a medication used to help your pet's heart pump more effectively and to open up blood vessels, reducing the workload on the heart. * **Administration:** Give this medication on an **empty stomach**, ideally one hour before feeding, to ensure it is properly absorbed. * **Strict Schedule:** Try to give the doses exactly 12 hours apart as directed by your veterinarian. * **Lifelong Therapy:** Pimobendan is a treatment to manage heart failure, not a cure. It is usually required for the rest of your pet's life. **Do not stop giving this medication** without consulting your veterinarian. * **Monitoring at Home:** Watch your pet's breathing rate while they are sleeping (Resting Respiratory Rate). If it consistently rises above 30 breaths per minute, contact your veterinarian. * **Safety:** Keep out of reach of children and other animals.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Management of myocardial failure (DCM), especially if not associated with taurine deficiency
- Heart failure associated with systolic dysfunction (Off-label)
- Management of the signs of mild, moderate or severe congestive heart failure due to AV valve insufficiency or dilated cardiomyopathy
- Treatment of congestive heart failure secondary to myxomatous mitral valve disease (MMVD)
- Treatment of heart failure secondary to dilated cardiomyopathy or chronic mitral valve insufficiency
- General dosing
- Adjunctive drug for the emergency treatment of CHF (if not overtly critical and a strong positive oral inotrope is needed)
- Adjunctive treatment of acute or chronic stage D heart failure (refractory to standard treatment)
- Congestive heart failure (MMVD or DCM) / Preclinical DCM / Preclinical MMVD
- Congestive heart failure (MMVD or DCM) / Preclinical DCM / Preclinical MMVD
給藥方式
可能的副作用
- Poor appetite
- Lethargy
- Diarrhea
- Dyspnea
- Azotemia
- Weakness and ataxia
- Pleural effusion
- Syncope
- Cough
- Ascites
- Heart murmur
- Arrhythmias (atrial fibrillation, increased ventricular ectopic beats)
- Worsening mitral valve lesions (acute hemorrhages, endocardial papilloform hyperplasia) with chronic use
- Moderate positive chronotropic effect (tachycardia)
注意事項與禁忌
- Hypersensitivity to pimobendan
- Hypertrophic cardiomyopathy (HCM)
- Aortic stenosis
- Any condition where augmentation of cardiac output is inappropriate for functional or anatomic reasons
- Any condition where augmentation of cardiac output via increased contractility is not possible anatomically or functionally
- Use with caution in patients with **uncontrolled cardiac arrhythmias**. Safety has not been evaluated in: * Dogs younger than 6 months of age * Dogs with congenital heart defects * Dogs with diabetes mellitus or other serious metabolic diseases * Breeding, pregnant, or lactating animals (high doses in lab animals caused increased resorptions) > **Note:** Patients treated chronically should be regularly examined for worsening mitral valvular lesions and regurgitation.
藥物相互作用
- Verapamil: Calcium antagonist; attenuates pimobendan-induced increases in cardiac contractility.
- Propranolol: Beta-antagonist; attenuates pimobendan-induced increases in cardiac contractility.
- Diltiazem: Calcium channel blocker; assumed to potentially attenuate positive inotropic effects.
- Atenolol: Beta-blocker; assumed to potentially attenuate positive inotropic effects.
- Beta-blockers (e.g., atenolol, propranolol): Attenuates the positive inotropic effects of pimobendan
- Calcium-channel blockers (e.g., verapamil, diltiazem): Attenuates the positive inotropic effects of pimobendan
常見問題
Pimobendan用於寵物有甚麼用途？
Pimobendan is a medication used to help your pet's heart pump more effectively and to open up blood vessels, reducing the workload on the heart. * **Administration:** Give this medication on an **empty stomach**, ideally one hour before feeding, to ensure it is properly absorbed. * **Strict Schedule:** Try to give the doses exactly 12 hours apart as directed by your veterinarian. * **Lifelong Therapy:** Pimobendan is a treatment to manage heart failure, not a cure. It is usually required for the rest of your pet's life. **Do not stop giving this medication** without consulting your veterinarian. * **Monitoring at Home:** Watch your pet's breathing rate while they are sleeping (Resting Respiratory Rate). If it consistently rises above 30 breaths per minute, contact your veterinarian. * **Safety:** Keep out of reach of children and other animals.
Pimobendan對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。