Lactulose
別名: Cephulac, Constulose, Enulose, Kristalose, Generiac, Duphalac, Lactugal, Laevolac
### What to Expect * **The Goal**: The ideal outcome of lactulose therapy is **2 to 3 soft, semi-formed stools per day** (think of the consistency of soft-serve ice cream). * **Adjustments**: Your veterinarian will likely have you adjust the dose slightly up or down based on your pet's stool consistency. ### Important Warnings * **Watch for Diarrhea**: If your pet develops watery diarrhea, stop the medication and contact your veterinarian immediately, as this can lead to dangerous dehydration. * **Liver Disease**: If your pet is taking this for liver disease (hepatic encephalopathy) and their neurological signs worsen (e.g., stumbling, staring into space, head pressing) or they are having fewer than 2 soft stools a day, contact your vet right away. ### Tips for Cats * Cats often hate the sticky, sweet taste of the liquid syrup and may drool excessively or run away. * If you are struggling to give the liquid, ask your veterinarian about **lactulose crystals** (*Kristalose*), which can be easily mixed into canned food and are usually much better accepted.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Hepatic encephalopathy
- Constipation
- Constipation
- Constipation
- Chronic constipation (maintaining soft stools)
- Hepatic encephalopathy / Constipation
- Hepatic encephalopathy; to stimulate appetite, improve intestinal flora
- Laxative
- Hepatic encephalopathy
- Hepatic encephalopathy
- Hepatic encephalopathy crisis
- Hepatic encephalopathy
- Hepatic encephalopathy
- Constipation
給藥方式
可能的副作用
- Flatulence
- Gastric distention
- Abdominal cramping
- Diarrhea (dose-dependent)
- Dehydration (secondary to excessive diarrhea)
- Hypersalivation/aversion in cats (due to taste/texture)
- Diarrhoea
- Dehydration (with excessive dosing)
注意事項與禁忌
- Patients requiring a low-galactose diet
- Use with caution in diabetic patients (contains free lactose and galactose)
- Use with caution in patients with preexisting fluid and electrolyte imbalances
- Severely encephalopathic animals at risk of inhalation/aspiration
- Gastrointestinal obstruction
- Animals at risk of gastrointestinal perforation
- > **Diabetic Patients**: Lactulose syrup contains some free lactose and galactose, which may alter insulin requirements. > **Electrolyte Imbalances**: Lactulose-induced diarrhea can exacerbate preexisting fluid and electrolyte imbalances. Monitor hydration and serum electrolytes during long-term therapy. > **Feline Administration**: The syrup is notoriously difficult to administer to cats due to taste aversion; consider using lactulose crystals mixed with food.
藥物相互作用
- Oral Antacids: Non-adsorbable antacids may reduce the colonic acidification effects and overall efficacy of lactulose.
- Other Laxatives: Should not be used concurrently; loose stools may be falsely attributed to lactulose, resulting in inadequate dosing for hepatic encephalopathy.
- Neomycin (and other oral antibiotics): Theoretically, oral antibiotics could eliminate the colonic bacteria required to metabolize lactulose, reducing its efficacy. However, clinical synergy is often observed when treating hepatic encephalopathy. Enhanced monitoring is recommended.
- Oral antibiotics (e.g., neomycin): Synergy may occur when used together for hepatic encephalopathy.
- Insulin: Lactulose syrup contains free lactose and galactose, which may alter insulin requirements in diabetic patients.
- 5-aminosalicylic acid (and other pH-dependent colon-release drugs): Can be inactivated because lactulose decreases the pH of the colon.
常見問題
Lactulose用於寵物有甚麼用途？
### What to Expect * **The Goal**: The ideal outcome of lactulose therapy is **2 to 3 soft, semi-formed stools per day** (think of the consistency of soft-serve ice cream). * **Adjustments**: Your veterinarian will likely have you adjust the dose slightly up or down based on your pet's stool consistency. ### Important Warnings * **Watch for Diarrhea**: If your pet develops watery diarrhea, stop the medication and contact your veterinarian immediately, as this can lead to dangerous dehydration. * **Liver Disease**: If your pet is taking this for liver disease (hepatic encephalopathy) and their neurological signs worsen (e.g., stumbling, staring into space, head pressing) or they are having fewer than 2 soft stools a day, contact your vet right away. ### Tips for Cats * Cats often hate the sticky, sweet taste of the liquid syrup and may drool excessively or run away. * If you are struggling to give the liquid, ask your veterinarian about **lactulose crystals** (*Kristalose*), which can be easily mixed into canned food and are usually much better accepted.
Lactulose對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。