Clindamycin
別名: Antirobe, Cleocin, Clintabs, Clinsol, Clinacin, Clindacyl, Clindaseptin, Mycinor, Zodon
> **Important Administration Note:** If using oral tablets or capsules, especially in cats, **always follow the medication with at least 6 mL (a little more than a teaspoonful) of liquid** or hide it in a small meatball of wet food. Giving a dry pill can cause the medication to stick in the esophagus, leading to severe ulcers and strictures. * **Watch for GI Upset:** Report any incidence of severe, protracted, or bloody diarrhea to your veterinarian immediately. * **Complete the Course:** Give the medication exactly as prescribed for the full duration, even if your pet seems to feel better, to prevent resistant infections.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Susceptible bacterial infections
- Infected wounds, abscesses and dental infections
- Sepsis
- Anaerobic infections
- Intra-abdominal sepsis
- Pancreatitis
- Susceptible respiratory infections
- Surgical prophylaxis for gram-positive aerobes and anaerobic coverage
- Toxoplasmosis (to decrease zoonotic risk by reducing shedding period)
- Clinical toxoplasmosis
- Enteroepithelial toxoplasmosis
- Systemic toxoplasmosis
- Susceptible infections
給藥方式
可能的副作用
- Gastroenteritis (emesis, loose stools, bloody diarrhea)
- Esophageal injuries (esophagitis, strictures) in cats if dry-pilled
- Hypersalivation or lip smacking in cats after oral administration
- Pain at IM injection site
- Mild, clinically insignificant increases in liver enzymes (AST, ALT, ALP)
- Colitis
- Vomiting
- Diarrhoea
- Oesophagitis (especially in cats)
- Oesophageal stricture (especially in cats)
注意事項與禁忌
- Horses
- Rabbits
- Hamsters
- Chinchillas
- Guinea pigs
- Ruminants
- Patients hypersensitive to lincosamides
- Neonatal small animals (generally avoided)
- Known hypersensitivity to lincosamides
- > **Esophageal Injury Warning:** Clindamycin has been implicated in causing esophagitis and esophageal strictures in small animals (especially cats). **Avoid dry 'pilling'**; always administer with food or a water bolus. * **Hepatic/Renal Impairment:** Patients with very severe renal and/or hepatic disease should receive the drug with caution. Consider dosage reduction and monitor serum clindamycin levels during high-dose therapy. * **Species Restrictions:** Fatal gastrointestinal effects can occur in horses, ruminants, and small herbivores (rabbits, rodents). Do not use in these species.
藥物相互作用
- Cyclosporine: Clindamycin may reduce cyclosporine levels
- Erythromycin: In vitro antagonism when used with clindamycin; concomitant use should probably be avoided
- Neuromuscular blocking agents (e.g., pancuronium): Clindamycin possesses intrinsic neuromuscular blocking activity and should be used cautiously with other neuromuscular blocking agents
- Non-depolarizing muscle relaxants (e.g., tubocurarine): May enhance the neuromuscular blocking effect
- Neostigmine: May antagonize the effects of neostigmine
- Pyridostigmine: May antagonize the effects of pyridostigmine
- Macrolides (e.g., erythromycin): Antagonistic antimicrobial effects due to competing binding sites
- Chloramphenicol: Antagonistic antimicrobial effects due to competing binding sites
- Other lincosamides: Antagonistic antimicrobial effects
- Tubocurarine (and other non-depolarizing muscle relaxants): May enhance the neuromuscular blocking effect
- Lincomycin: Complete cross-resistance and antagonistic effect
常見問題
Clindamycin用於寵物有甚麼用途？
> **Important Administration Note:** If using oral tablets or capsules, especially in cats, **always follow the medication with at least 6 mL (a little more than a teaspoonful) of liquid** or hide it in a small meatball of wet food. Giving a dry pill can cause the medication to stick in the esophagus, leading to severe ulcers and strictures. * **Watch for GI Upset:** Report any incidence of severe, protracted, or bloody diarrhea to your veterinarian immediately. * **Complete the Course:** Give the medication exactly as prescribed for the full duration, even if your pet seems to feel better, to prevent resistant infections.
Clindamycin對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。