Myasthenia Gravis
Juga dikenali sebagai: MG, Acquired Myasthenia Gravis, Congenital Myasthenia Gravis
Ringkasnya
Myasthenia gravis is an uncommon neuromuscular disorder in dogs and cats that causes progressive muscle weakness during exercise. It can be inherited or autoimmune, often leading to swallowing difficulties and a high risk of life-threatening aspiration pneumonia.
TL;DR. Gangguan neuromuskular dengan kelemahan letih; risiko tinggi megaesofagus dan pneumonia aspirasi.
Kelemahan bertambah dengan senaman.
Apakah ia?
Kegagalan persimpangan neuromuskular kerana reseptor asetilkolin kurang (kongenital atau autoimun diperolehi).
Punca dan faktor risiko
Autoimun; timoma/kanser lain; genetik kongenital. Baka: German Shepherd, golden, labrador, dachshund; kongenital Jack Russell, springer, fox terrier.
Tanda
- Kelemahan anggota (kardinal)
- Megaesofagus, regurgitasi, pneumonia aspirasi
- Air liur, disfagia, suara berubah
Megaesofagus ialah komplikasi serius.
Diagnosis
Antibodi AChR (emas); ujian edrophonium; x-ray toraks; elektrodiagnostik.
X-ray menilai megaesofagus dan pneumonia.
Rawatan
Pyridostigmine; imunosupresi berhati-hati; suapan tegak; sokongan pneumonia.
Prognosis
Berubah-ubah; lebih buruk dengan pneumonia/timoma; remisi bentuk diperolehi sering dalam ~18 bulan.
Pencegahan
Tiada primer; pembiakan bertanggungjawab jika kongenital.
Bila hubungi doktor haiwan
Sesak nafas, batuk, regurgitasi kerap, tidak boleh bangun: mendesak.
Sumber
- Internal Medicine, 5th Edition, pages 1120, 1122, 1470.
My highlights & notes
Tanda & simptom
Baka berisiko lebih tinggi
Cara didiagnosis
- Serum acetylcholine receptor (AChR) antibody titerStandard emas
- Edrophonium response testing (Tensilon test)
- Electrodiagnostic testing (repetitive nerve stimulation)
- Intercostal muscle biopsy
- Thoracic radiographs
Pendekatan rawatan
Rawatan mesti dipreskripsikan doktor haiwan berlesen. Dos khusus sengaja tidak dipaparkan.
Soalan lazim
What is Myasthenia Gravis?
Myasthenia gravis is an uncommon neuromuscular disorder in dogs and cats that causes progressive muscle weakness during exercise. It can be inherited or autoimmune, often leading to swallowing difficulties and a high risk of life-threatening aspiration pneumonia.
What are the symptoms of Myasthenia Gravis?
Appendicular muscle weakness、Excessive salivation、Megaesophagus、Bringing up undigested food、aspiration pneumonia、Trouble swallowing (dysphagia)、Dysphonia、Facial muscle weakness
How is Myasthenia Gravis diagnosed?
Serum acetylcholine receptor (AChR) antibody titer、Edrophonium response testing (Tensilon test)、Electrodiagnostic testing (repetitive nerve stimulation)、Intercostal muscle biopsy、Thoracic radiographs
How is Myasthenia Gravis treated?
Rawatan mesti dipreskripsikan doktor haiwan berlesen. Dos khusus sengaja tidak dipaparkan.
Sumber
- Internal Medicine 5th · p. 1120
- Internal Medicine 5th · p. 1122
- Internal Medicine 5th · p. 1470
- Internal Medicine 5th · p. 1470
- Internal Medicine 5th · p. 1120
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