Myasthenia Gravis
Juga dikenal sebagai: MG, Acquired Myasthenia Gravis, Congenital Myasthenia Gravis
Singkatnya
Myasthenia gravis is an uncommon neuromuscular disorder in dogs and cats that causes progressive muscle weakness during exercise. It can be inherited or autoimmune, often leading to swallowing difficulties and a high risk of life-threatening aspiration pneumonia.
TL;DR. Gangguan neuromuskular dengan kelemahan lelah; risiko tinggi megaesofagus dan pneumonia aspirasi.
Kelemahan memburuk dengan olahraga.
Apa itu?
Kegagalan sambungan neuromuskular karena reseptor asetilkolin sedikit (kongenital atau autoimun didapat).
Penyebab dan faktor risiko
Autoimun; timoma/kanker lain; genetik kongenital. Ras: German Shepherd, golden, labrador, dachshund; kongenital Jack Russell, springer, fox terrier.
Tanda
- Kelemahan anggota (kardinal)
- Megaesofagus, regurgitasi, pneumonia aspirasi
- Air liur, disfagia, suara berubah
Megaesofagus adalah komplikasi serius.
Diagnosis
Antibodi AChR (emas); uji edrophonium; rontgen toraks; elektrodiagnostik.
Rontgen menilai megaesofagus dan pneumonia.
Pengobatan
Pyridostigmine; imunosupresi hati-hati; pemberian pakan tegak; dukungan pneumonia.
Prognosis
Bervariasi; lebih buruk dengan pneumonia/timoma; remisi bentuk didapat sering dalam ~18 bulan.
Pencegahan
Tanpa primer; breeding bertanggung jawab jika kongenital.
Kapan ke dokter hewan
Sesak napas, batuk, regurgitasi sering, tidak bisa berdiri: mendesak.
Sumber
- Internal Medicine, 5th Edition, pages 1120, 1122, 1470.
My highlights & notes
Tanda & gejala
Ras berisiko lebih tinggi
Cara didiagnosis
- Serum acetylcholine receptor (AChR) antibody titerStandar emas
- Edrophonium response testing (Tensilon test)
- Electrodiagnostic testing (repetitive nerve stimulation)
- Intercostal muscle biopsy
- Thoracic radiographs
Pendekatan pengobatan
Pengobatan harus diresepkan dokter hewan berlisensi. Dosis spesifik sengaja tidak ditampilkan.
Pertanyaan umum
What is Myasthenia Gravis?
Myasthenia gravis is an uncommon neuromuscular disorder in dogs and cats that causes progressive muscle weakness during exercise. It can be inherited or autoimmune, often leading to swallowing difficulties and a high risk of life-threatening aspiration pneumonia.
What are the symptoms of Myasthenia Gravis?
Appendicular muscle weakness、Excessive salivation、Megaesophagus、Bringing up undigested food、aspiration pneumonia、Trouble swallowing (dysphagia)、Dysphonia、Facial muscle weakness
How is Myasthenia Gravis diagnosed?
Serum acetylcholine receptor (AChR) antibody titer、Edrophonium response testing (Tensilon test)、Electrodiagnostic testing (repetitive nerve stimulation)、Intercostal muscle biopsy、Thoracic radiographs
How is Myasthenia Gravis treated?
Pengobatan harus diresepkan dokter hewan berlisensi. Dosis spesifik sengaja tidak ditampilkan.
Sumber
- Internal Medicine 5th · p. 1120
- Internal Medicine 5th · p. 1122
- Internal Medicine 5th · p. 1470
- Internal Medicine 5th · p. 1470
- Internal Medicine 5th · p. 1120
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