雙甲脒

用途

• Generalized demodicosis (Labeled Protocol)
• Generalized demodicosis (Extra-label Protocol 1)
• Generalized demodicosis (Extra-label Protocol 2)
• Otic demodicosis
• Generalized mite infestations (canine demodicosis, sarcoptic acariasis and cheyletiellosis)
• Follicular demodicosis (Demodex cati)
• Surface demodicosis (Demodex gatoi)
• Mite treatment (Mice, Rats, Gerbils, Hamsters, Guinea pigs, Chinchillas)

給藥方式

可能的副作用

• Transient sedation (up to 72 hours)
• Ataxia
• Bradycardia
• Vomiting and diarrhea
• Hypothermia
• Transient hyperglycemia
• Pruritus, erythema, and edema at application site
• Seizures (rare)

注意事項與禁忌

• Cats and rabbits (highly toxic, though extra-label protocols exist)
• Chihuahuas and toy breeds (use with extreme caution)
• Puppies less than 4 months of age
• Dogs with deep pyodermas and draining tracts (treat infection first)
• Brittle diabetic patients
• Pregnant or nursing animals
• > **Safety Warning:** Liquid concentrates are flammable until diluted. * Clients must wear rubber gloves when mixing and applying. * Wash hands and arms thoroughly after application. * Do not stress animals for at least 24 hours post-application. * Use ophthalmic protectants (e.g., petrolatum ointment) if treating near the eyes. * Dispose of unused diluted solution by flushing down the drain and do not reuse containers.

藥物相互作用

• Corticosteroids: Immunosuppression can worsen demodicosis; concomitant use is contraindicated.
• Selegiline: Concurrent use of MAO inhibitors increases risk of toxicity.
• Amitriptyline: Concurrent use with tricyclic antidepressants is not recommended.
• Clomipramine: Concurrent use with tricyclic antidepressants is not recommended.
• Alpha-2 agonist sedatives (e.g., dexmedetomidine, xylazine): Additive or synergistic CNS depression and cardiovascular effects (bradycardia).
• Other ectoparasiticides: Potential for increased toxicity.

常見問題