Famotidine

用途

• To reduce gastric acid production
• To reduce gastric acid production
• For esophagitis
• For acute reflex esophagitis
• Adjunctive treatment of GI effects associated with chronic progressive renal disease
• Adjunctive treatment of GI effects associated with chronic progressive renal disease
• All uses (ulcers, gastritis, oesophagitis, hypersecretory conditions)
• For stress induced ulcers
• In combination with antibiotics for Helicobacter treatment
• As an adjunct in ulcer treatment
• As an adjunct in ulcer treatment
• Rabbits: For stress induced ulcer prevention once critically ill animal has stabilized

給藥方式

可能的副作用

• Bradycardia (if infused too rapidly IV)
• GI effects (anorexia, vomiting, diarrhea)
• Headache
• Dry mouth or skin
• Intravascular hemolysis (rare, anecdotally reported in cats given IV)
• Transient increase in serum gastrin (returns to baseline by 14 days)
• Generally has a very good safety profile with fewer side effects than cimetidine

注意事項與禁忌

• Known hypersensitivity to H2 blockers
• Known hypersensitivity to famotidine or other H2 receptor antagonists
• Use cautiously in **geriatric patients** and those with significantly **impaired hepatic or renal function**; consider dosage reduction in patients with significant renal dysfunction. Famotidine may have negative inotropic effects and some cardioarrhythmogenic properties; use with caution in patients with **cardiac disease**. When administering IV to cats, infuse slowly (over 5 minutes) to minimize the rare risk of intravascular hemolysis.

藥物相互作用

• Azole Antifungals (ketoconazole, itraconazole, fluconazole): Famotidine raises gastric pH, which may decrease the absorption of these agents. Administer the azole one hour prior to famotidine.
• Cefpodoxime, Cefuroxime: Famotidine may decrease the absorption of these cephalosporins. Taking with food may alleviate this effect.
• Iron Salts (Oral): Famotidine may decrease the absorption of oral iron. Administer iron at least one hour prior to famotidine.

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