비타민 A / 이소트레티노인

용도

• Antioxidant support, liver disease, or malabsorption (EPI)
• Antioxidant support or malabsorption

투여 방법

가능한 부작용

• Teratogenicity (fetal malformations)
• Keratoconjunctivitis sicca (KCS / dry eye)
• Hepatotoxicity
• Hyperlipidaemia
• Hypercalcaemia (due to bone calcium loss with prolonged use)
• Skin redness and pigmentation
• Haematological abnormalities
• Nervous system changes
• Bone changes
• Thrombosis
• Anaphylactoid reactions

주의사항 및 금기

• Pregnant animals
• Breeding animals
• Patients at high risk for thrombosis
• Neonates
• > **TERATOGENIC WARNING:** Gloves should be worn when applying topical preparations. Pregnant women should avoid handling these medications entirely. - Avoid contact with eyes, mouth, or mucous membranes. - Avoid concurrent use of oral and topical preparations due to cumulative toxicity. - **Do not use** formulations of vitamins A, D3, and E authorized for farm animals or horses in small animals, as they are too concentrated and risk severe toxicity. - Minimize exposure of the drug to sunlight.

약물 상호작용

• Ciclosporin: Oral vitamin A may alter ciclosporin levels; requires close monitoring.
• Other topical drugs: Do not use topical vitamin A preparations simultaneously with other topical drugs.
• Vitamin A: May enhance vitamin A absorption, utilization, and storage.

자주 묻는 질문