클로피도그렐

용도

• As an anti-platelet agent
• Thromboprophylaxis
• To prevent thrombus formation
• To prevent thrombus formation (combination therapy)
• To prevent thrombus formation
• Thromboprophylaxis

투여 방법

가능한 부작용

• Vomiting
• Anorexia
• Bleeding/hemorrhage
• Diarrhea
• Rashes
• Thrombotic thrombocytopenic purpura (TTP) - rare in humans

주의사항 및 금기

• Active pathologic bleeding
• Known hypersensitivity to the drug
• > **Bleeding Risk**: Use with caution in patients at risk for bleeding from trauma, surgery, or other pathological conditions. > **Pregnancy/Nursing**: FDA Category B in humans. Probably safe in nursing veterinary patients, but weigh potential risks to offspring or use a milk replacer.

약물 상호작용

• Aspirin: Increased risk for bleeding; however, many patients take both medications intentionally for dual antiplatelet therapy.
• Heparin / Low Molecular Weight Heparins (LMWH): Clopidogrel appears safe to use concurrently with heparin.
• NSAIDs: Increased risk for bleeding; clopidogrel may interfere with NSAID metabolism.
• Phenytoin: Clopidogrel may interfere with phenytoin metabolism.
• Proton Pump Inhibitors (e.g., omeprazole): May decrease the efficacy of clopidogrel by inhibiting CYP2C19, the enzyme needed to convert clopidogrel to its active metabolite.
• Torsemide: Clopidogrel may interfere with torsemide metabolism.
• Warfarin: Increased risk for bleeding; clopidogrel may interfere with warfarin metabolism.
• Anticoagulants: High risk of bleeding complications

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