アセチルシステイン

使用用途

• Acetaminophen toxicity
• Acetaminophen toxicity
• Acetaminophen toxicity
• Phenol toxicity
• Hepatotoxicity secondary to xylitol poisoning
• Degenerative myelopathy (anecdotal)
• Mucolytic
• Paracetamol poisoning
• KCS
• Acetaminophen toxicity
• Phenol toxicity
• Adjunctive treatment of hepatic lipidosis
• Mucolytic
• Paracetamol poisoning

投与方法

考えられる副作用

• Nausea and vomiting (especially with oral administration due to poor palatability)
• Urticaria (rare)
• Bronchospasm, chest tightness, and bronchial/tracheal irritation (when inhaled)
• Blood pressure changes and allergic reactions (reported with IV boluses in humans)

注意事項と禁忌

• Hypersensitivity to the drug (specifically for pulmonary indications)
• Use with caution in animals with pre-existing bronchospastic diseases (e.g., feline asthma) when administering via the pulmonary route, as it may trigger bronchospasm. Oral administration can be challenging due to the extremely foul taste and odor (sulfur/rotten eggs); administration via a gastric or duodenal tube is often necessary. If using the inhalation solution for intravenous administration, it is highly recommended to use a 0.2-micron in-line filter. Use caution in nursing dams as it is unknown if the drug enters milk.

薬物相互作用

• Activated Charcoal: May adsorb orally administered acetylcysteine, potentially reducing its systemic absorption and efficacy. A 2-3 hour wait between charcoal and oral acetylcysteine is recommended, or acetylcysteine should be given intravenously.

よくある質問