Pimobendan
Také známé jako: Vetmedin, Acardi, Cardisure, Pimocard, Fortekor-Plus
Pimobendan is a medication used to help your pet's heart pump more effectively and to open up blood vessels, reducing the workload on the heart. * **Administration:** Give this medication on an **empty stomach**, ideally one hour before feeding, to ensure it is properly absorbed. * **Strict Schedule:** Try to give the doses exactly 12 hours apart as directed by your veterinarian. * **Lifelong Therapy:** Pimobendan is a treatment to manage heart failure, not a cure. It is usually required for the rest of your pet's life. **Do not stop giving this medication** without consulting your veterinarian. * **Monitoring at Home:** Watch your pet's breathing rate while they are sleeping (Resting Respiratory Rate). If it consistently rises above 30 breaths per minute, contact your veterinarian. * **Safety:** Keep out of reach of children and other animals.
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
Veterinary professional? See the full dosing-by-species reference on VetSheet →
What it is used for
- Management of myocardial failure (DCM), especially if not associated with taurine deficiency
- Heart failure associated with systolic dysfunction (Off-label)
- Management of the signs of mild, moderate or severe congestive heart failure due to AV valve insufficiency or dilated cardiomyopathy
- Treatment of congestive heart failure secondary to myxomatous mitral valve disease (MMVD)
- Treatment of heart failure secondary to dilated cardiomyopathy or chronic mitral valve insufficiency
- General dosing
- Adjunctive drug for the emergency treatment of CHF (if not overtly critical and a strong positive oral inotrope is needed)
- Adjunctive treatment of acute or chronic stage D heart failure (refractory to standard treatment)
- Congestive heart failure (MMVD or DCM) / Preclinical DCM / Preclinical MMVD
- Congestive heart failure (MMVD or DCM) / Preclinical DCM / Preclinical MMVD
How it is given
Possible side effects
- Poor appetite
- Lethargy
- Diarrhea
- Dyspnea
- Azotemia
- Weakness and ataxia
- Pleural effusion
- Syncope
- Cough
- Ascites
- Heart murmur
- Arrhythmias (atrial fibrillation, increased ventricular ectopic beats)
- Worsening mitral valve lesions (acute hemorrhages, endocardial papilloform hyperplasia) with chronic use
- Moderate positive chronotropic effect (tachycardia)
- Vomiting (dose-dependent)
- Reduced appetite or lethargy (rare)
Cautions & contraindications
- Hypersensitivity to pimobendan
- Hypertrophic cardiomyopathy (HCM)
- Aortic stenosis
- Any condition where augmentation of cardiac output is inappropriate for functional or anatomic reasons
- Any condition where augmentation of cardiac output via increased contractility is not possible anatomically or functionally
- Use with caution in patients with **uncontrolled cardiac arrhythmias**. Safety has not been evaluated in: * Dogs younger than 6 months of age * Dogs with congenital heart defects * Dogs with diabetes mellitus or other serious metabolic diseases * Breeding, pregnant, or lactating animals (high doses in lab animals caused increased resorptions) > **Note:** Patients treated chronically should be regularly examined for worsening mitral valvular lesions and regurgitation.
Drug interactions
- Verapamil: Calcium antagonist; attenuates pimobendan-induced increases in cardiac contractility.
- Propranolol: Beta-antagonist; attenuates pimobendan-induced increases in cardiac contractility.
- Diltiazem: Calcium channel blocker; assumed to potentially attenuate positive inotropic effects.
- Atenolol: Beta-blocker; assumed to potentially attenuate positive inotropic effects.
- Beta-blockers (e.g., atenolol, propranolol): Attenuates the positive inotropic effects of pimobendan
- Calcium-channel blockers (e.g., verapamil, diltiazem): Attenuates the positive inotropic effects of pimobendan
Časté otázky
What is Pimobendan used for in pets?
Pimobendan is a medication used to help your pet's heart pump more effectively and to open up blood vessels, reducing the workload on the heart. • Administration: Give this medication on an empty stomach, ideally one hour before feeding, to ensure it is properly absorbed. • Strict Schedule: Try to give the doses exactly 12 hours apart as directed by your veterinarian. • Lifelong Therapy: Pimobendan is a treatment to manage heart failure, not a cure. It is usually required for the rest of your pet's life. Do not stop giving this medication without consulting your veterinarian. • Monitoring at Home: Watch your pet's breathing rate while they are sleeping (Resting Respiratory Rate). If it consistently rises above 30 breaths per minute, contact your veterinarian. • Safety: Keep out of reach of children and other animals.
Is Pimobendan safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
Článek je obecná edukace a nenahrazuje veterinární radu. Pokud je zvíře nemocné, kontaktujte veterináře.
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