雷尼替丁

用途

• For ulcer disease/esophagitis
• For ulcer disease/esophagitis
• For ulcer disease/esophagitis
• As a prokinetic agent to stimulate colonic motility
• As a prokinetic agent to stimulate colonic motility
• All uses
• All uses
• For Helicobacter mustelae
• Foals
• Foals
• Adults
• As a prokinetic in rabbits
• For suspected gastric ulceration in rabbits
• For esophagitis

給藥方式

可能的副作用

• Vomiting (associated with rapid IV boluses in small animals)
• Pain at the injection site (IM administration)
• Mental confusion (rare, documented in humans)
• Headache (rare, documented in humans)
• Agranulocytosis (rare)
• Transient cardiac arrhythmias (if given too rapidly IV)
• Cardiac arrhythmias (rare, typically with rapid IV)
• Hypotension (rare, typically with rapid IV)

注意事項與禁忌

• Hypersensitivity to ranitidine
• No specific contraindications available in the monograph
• Use cautiously and consider reduced dosages in patients with **diminished renal function** or **hepatic insufficiency**, as the drug may accumulate. **Geriatric patients** may be more susceptible to adverse effects. High-dose, chronic IV therapy (longer than 5 days) has caused increased serum ALT levels in humans; monitoring liver enzymes is recommended in these scenarios. Use with caution in nursing veterinary patients, as ranitidine is excreted in breast milk (milk:plasma ratio of 5:1 to 12:1).

藥物相互作用

• Acetaminophen: Ranitidine (dose-dependent) may inhibit acetaminophen metabolism.
• Antacids: High doses may decrease the absorption of ranitidine; administer at least 2 hours apart.
• Ketoconazole: Absorption of ketoconazole may be reduced secondary to increased gastric pH.
• Itraconazole: Absorption of itraconazole may be reduced secondary to increased gastric pH.
• Metoprolol: Ranitidine may increase metoprolol half-life and peak serum levels.
• Nifedipine: Ranitidine may increase nifedipine AUC by 30%.
• Propantheline: Delays the absorption but increases the peak serum level of ranitidine; relative bioavailability may be increased by 23%.
• Vitamin B-12: Long-term ranitidine use may reduce oral absorption of Vitamin B-12.
• Sucralfate: May affect absorption; advisable to administer sucralfate 2 hours before H2 blockers
• Digoxin: Ranitidine may reduce absorption or effect; stagger oral doses by 2 hours
• Metoclopramide: Ranitidine may reduce absorption or effect; stagger oral doses by 2 hours

常見問題