Ranitidine
別名: Zantac, Zantac 75, Zantac EFFERdose
**Ranitidine** is a medication used to reduce stomach acid and help food move through the digestive tract more effectively. * **Administration:** Give this medication exactly as prescribed by your veterinarian. Do not skip doses, as stomach acid levels can rebound and symptoms may return. * **Timing:** It can be given with or without food. If your pet is also taking antacids, give them at least 2 hours apart from ranitidine. * **Side Effects:** Ranitidine is generally very safe and well-tolerated. Side effects are rare but can include mild stomach upset. * **Storage:** Keep tablets in a tightly sealed container at room temperature, away from direct light. > **Note:** Always consult your veterinarian before giving any new medications or supplements, though ranitidine has fewer drug interactions than older antacids like cimetidine.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- For ulcer disease/esophagitis
- For ulcer disease/esophagitis
- For ulcer disease/esophagitis
- As a prokinetic agent to stimulate colonic motility
- As a prokinetic agent to stimulate colonic motility
- All uses
- All uses
- For Helicobacter mustelae
- Foals
- Foals
- Adults
- As a prokinetic in rabbits
- For suspected gastric ulceration in rabbits
- For esophagitis
給藥方式
可能的副作用
- Vomiting (associated with rapid IV boluses in small animals)
- Pain at the injection site (IM administration)
- Mental confusion (rare, documented in humans)
- Headache (rare, documented in humans)
- Agranulocytosis (rare)
- Transient cardiac arrhythmias (if given too rapidly IV)
- Cardiac arrhythmias (rare, typically with rapid IV)
- Hypotension (rare, typically with rapid IV)
注意事項與禁忌
- Hypersensitivity to ranitidine
- No specific contraindications available in the monograph
- Use cautiously and consider reduced dosages in patients with **diminished renal function** or **hepatic insufficiency**, as the drug may accumulate. **Geriatric patients** may be more susceptible to adverse effects. High-dose, chronic IV therapy (longer than 5 days) has caused increased serum ALT levels in humans; monitoring liver enzymes is recommended in these scenarios. Use with caution in nursing veterinary patients, as ranitidine is excreted in breast milk (milk:plasma ratio of 5:1 to 12:1).
藥物相互作用
- Acetaminophen: Ranitidine (dose-dependent) may inhibit acetaminophen metabolism.
- Antacids: High doses may decrease the absorption of ranitidine; administer at least 2 hours apart.
- Ketoconazole: Absorption of ketoconazole may be reduced secondary to increased gastric pH.
- Itraconazole: Absorption of itraconazole may be reduced secondary to increased gastric pH.
- Metoprolol: Ranitidine may increase metoprolol half-life and peak serum levels.
- Nifedipine: Ranitidine may increase nifedipine AUC by 30%.
- Propantheline: Delays the absorption but increases the peak serum level of ranitidine; relative bioavailability may be increased by 23%.
- Vitamin B-12: Long-term ranitidine use may reduce oral absorption of Vitamin B-12.
- Sucralfate: May affect absorption; advisable to administer sucralfate 2 hours before H2 blockers
- Digoxin: Ranitidine may reduce absorption or effect; stagger oral doses by 2 hours
- Metoclopramide: Ranitidine may reduce absorption or effect; stagger oral doses by 2 hours
常見問題
Ranitidine用於寵物有甚麼用途？
**Ranitidine** is a medication used to reduce stomach acid and help food move through the digestive tract more effectively. * **Administration:** Give this medication exactly as prescribed by your veterinarian. Do not skip doses, as stomach acid levels can rebound and symptoms may return. * **Timing:** It can be given with or without food. If your pet is also taking antacids, give them at least 2 hours apart from ranitidine. * **Side Effects:** Ranitidine is generally very safe and well-tolerated. Side effects are rare but can include mild stomach upset. * **Storage:** Keep tablets in a tightly sealed container at room temperature, away from direct light. > **Note:** Always consult your veterinarian before giving any new medications or supplements, though ranitidine has fewer drug interactions than older antacids like cimetidine.
Ranitidine對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。