米托蒽醌
別名: Novantrone
> **重要化療安全須知** > 您的寵物正在接受強效的化學治療藥物。在治療後的6天內，藥物及其代謝物可能會出現在寵物的尿液中，糞便中則可達7天。 * **排泄物處理：** 清理尿液、糞便或嘔吐物時，請務必戴上拋棄式手套。將排泄物雙層裝袋後再丟入一般垃圾桶。處理完畢後請徹底洗手。 * **顏色變化：** 您可能會發現寵物的尿液變成**藍綠色**，或者眼白（鞏膜）帶有輕微的藍色。**請不要驚慌**——這是藥物本身深藍色染料造成的正常且無害的現象。 * **需注意的副作用：** 密切觀察寵物是否有食慾不振、嘔吐、腹瀉或極度疲倦的現象。由於此藥物會降低白血球數量，您的寵物感染的風險會增加。 * **何時該聯絡獸醫師：** 如果您的寵物發燒、嚴重嘔吐/腹瀉，或者貓咪出現任何癲癇（抽搐）症狀，請立即聯絡您的獸醫師。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Soft-tissue sarcomas
- Effective dose (general)
- Single rescue agent for lymphoma
- Transitional cell carcinoma
- Lymphoma, squamous cell carcinoma, transitional cell carcinoma, mammary gland tumors, etc.
- Single rescue agent for lymphoma
- Rescue agent for canine lymphoma
- Transitional cell carcinoma after laser ablation of the primary tumor
給藥方式
可能的副作用
- Dose-dependent GI distress (vomiting, anorexia, diarrhea)
- Bone marrow depression (neutropenia, sepsis; nadir typically around day 10)
- Non-regenerative anemia
- Lethargy
- Seizures (specifically noted in cats)
- Blue-green discoloration of urine and sclera (benign)
- Tissue necrosis or phlebitis (if extravasated, though less severe than doxorubicin)
- Rarely: conjunctivitis, jaundice, renal failure, allergic reactions, thrombocytopenia
- Gastrointestinal signs (vomiting, anorexia, diarrhoea)
- Bone marrow depression (WBC nadir generally at 10 days)
- Seizure activity (reported in cats)
- Blue discoloration of urine and sclera (very rare)
- Acute renal failure (anecdotal in cats)
注意事項與禁忌
- Severe pre-existing myelosuppression
- Concurrent active infection
- Significantly impaired cardiac function
- Patients with prior extensive cytotoxic drug or radiation exposure (relative)
- Pregnancy (FDA Category D) and nursing mothers
- Pre-existing myelosuppression
- Concurrent infection
- Hepatic disease
- Impaired cardiac function
- **Handling Precautions:** Mitoxantrone is a cytotoxic agent. Strict adherence to safe handling, administration, and disposal protocols for chemotherapeutic agents is mandatory to protect veterinary personnel. **Extravasation Risk:** While generally considered an irritant rather than a severe vesicant like doxorubicin, extravasation can still cause tissue necrosis. Ensure a perfectly placed, clean IV catheter before administration. **Organ Function:** Use with caution in patients with impaired hepatic function or hyperuricemia/hyperuricuria.
藥物相互作用
- Doxorubicin, Daunorubicin, or Radiation Therapy: Cardiotoxicity risks may be enhanced in patients that have previously received these therapies to the mediastinum.
- Immunosuppressant Drugs (e.g., azathioprine, cyclophosphamide, corticosteroids): Concurrent use may significantly increase the risk of severe infection.
- Myelosuppressive Drugs (e.g., chloramphenicol, flucytosine, amphotericin B, colchicine): Additive bone marrow depression; use with extreme caution.
- Live Vaccines: Increased risk of vaccine-induced infection; should be used with extreme caution or avoided during therapy.
- Myelosuppressive agents: Increased risk of severe bone marrow depression
- Immunosuppressive agents: Increased risk of severe immunosuppression and infection
- Heparin: Chemically incompatible
常見問題
米托蒽醌用於寵物有什麼用途？
> 重要化療安全須知 > 您的寵物正在接受強效的化學治療藥物。在治療後的6天內，藥物及其代謝物可能會出現在寵物的尿液中，糞便中則可達7天。 • 排泄物處理： 清理尿液、糞便或嘔吐物時，請務必戴上拋棄式手套。將排泄物雙層裝袋後再丟入一般垃圾桶。處理完畢後請徹底洗手。 • 顏色變化： 您可能會發現寵物的尿液變成藍綠色，或者眼白（鞏膜）帶有輕微的藍色。請不要驚慌——這是藥物本身深藍色染料造成的正常且無害的現象。 • 需注意的副作用： 密切觀察寵物是否有食慾不振、嘔吐、腹瀉或極度疲倦的現象。由於此藥物會降低白血球數量，您的寵物感染的風險會增加。 • 何時該聯絡獸醫師： 如果您的寵物發燒、嚴重嘔吐/腹瀉，或者貓咪出現任何癲癇（抽搐）症狀，請立即聯絡您的獸醫師。
米托蒽醌對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。