加巴噴丁
別名: Neurontin, Aclonium, Equipax, Gantin, Gabarone, Neurostil, Progresse
**什麼是加巴噴丁？** 加巴噴丁是一種用於治療慢性神經痛的藥物，較少用於幫助控制癲癇發作。它也常被用來減少寵物在看獸醫等壓力事件前的恐懼和焦慮。 **如何給藥** * 可與食物一起或空腹服用。 * **絕對不要**將人類用的液體製劑（Neurontin）給您的狗服用（除非由獸醫藥局特別調配），因為它含有**木糖醇（xylitol）**，這是一種對狗具有劇毒甚至致命的人工甜味劑。 **需要注意什麼** * 最常見的副作用是**嗜睡**和**走路不穩（共濟失調）**。這些副作用通常很輕微，並且隨著您的寵物適應藥物後會有所改善。 * 如果您的寵物顯得過度昏睡或極度不協調，請聯繫您的獸醫。 **重要提示** * 如果您的寵物因癲癇發作而服用加巴噴丁，**請勿突然停藥**，因為這可能會引發嚴重的戒斷性癲癇發作。在更改劑量之前，請務必諮詢您的獸醫。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Ancillary therapy of refractory seizures
- Ancillary therapy of refractory seizures
- Ancillary therapy of refractory seizures
- Analgesic
- Adjunctive treatment of chronic or cancer pain
- Adjunctive analgesia associated with neuropathic pain
- Analgesic
- Analgesic
- Adjunctive seizure therapy / Chronic pain
- Ancillary therapy of refractory seizures
- Ancillary therapy of refractory seizures
- Ancillary therapy of refractory seizures
- Ancillary therapy of refractory seizures
給藥方式
可能的副作用
- Sedation
- Ataxia
- Dizziness (humans)
- Somnolence
- Peripheral edema (humans)
- Withdrawal-precipitated seizures (if abruptly discontinued)
- Increased rate of pancreatic adenocarcinoma (noted in male rats)
- Mild sedation
- False-positive urinary protein tests (reported in humans)
- Hepatic toxicity (rare, reported in humans)
注意事項與禁忌
- Hypersensitivity to gabapentin
- Use of xylitol-containing human oral solutions in dogs
- Oral solutions containing xylitol (highly toxic to dogs)
- > **WARNING**: Commercially available human oral solutions (e.g., Neurontin) often contain **xylitol** (up to 300 mg/mL), which is highly toxic to dogs, causing severe hypoglycemia and hepatotoxicity. Avoid use in dogs. * **Renal Insufficiency**: Eliminated primarily via the kidneys. Use with caution and consider dosage adjustments in patients with renal impairment. Dogs partially metabolize the drug (30-40%), so mild to moderate renal dysfunction may not require adjustment. * **Withdrawal**: Abrupt discontinuation can lead to withdrawal-precipitated seizures. Taper the dose gradually when discontinuing, especially in epileptic patients. * **Laboratory Alterations**: May cause false-positive urinary protein readings on Ames N-Multistix SG dipstick tests. Use a sulfosalicylic acid precipitation test instead.
藥物相互作用
- Antacids: Oral antacids given concurrently may decrease oral bioavailability of gabapentin by 20%; separate doses by at least 2 hours.
- Hydrocodone: Co-administration may increase gabapentin AUC and efficacy/adverse effects. Gabapentin may reduce hydrocodone AUC, potentially reducing its effectiveness.
- Morphine: May increase gabapentin levels.
- Antacids (containing aluminium and magnesium): Reduced absorption of gabapentin from the GI tract. Administer gabapentin at least 2 hours after antacids.
- Cimetidine: Reduced renal clearance of gabapentin (not considered clinically important).
常見問題
加巴噴丁用於寵物有什麼用途？
**什麼是加巴噴丁？** 加巴噴丁是一種用於治療慢性神經痛的藥物，較少用於幫助控制癲癇發作。它也常被用來減少寵物在看獸醫等壓力事件前的恐懼和焦慮。 **如何給藥** * 可與食物一起或空腹服用。 * **絕對不要**將人類用的液體製劑（Neurontin）給您的狗服用（除非由獸醫藥局特別調配），因為它含有**木糖醇（xylitol）**，這是一種對狗具有劇毒甚至致命的人工甜味劑。 **需要注意什麼** * 最常見的副作用是**嗜睡**和**走路不穩（共濟失調）**。這些副作用通常很輕微，並且隨著您的寵物適應藥物後會有所改善。 * 如果您的寵物顯得過度昏睡或極度不協調，請聯繫您的獸醫。 **重要提示** * 如果您的寵物因癲癇發作而服用加巴噴丁，**請勿突然停藥**，因為這可能會引發嚴重的戒斷性癲癇發作。在更改劑量之前，請務必諮詢您的獸醫。
加巴噴丁對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。