Gabapentin
別名: Neurontin, Aclonium, Equipax, Gantin, Gabarone, Neurostil, Progresse
**What is Gabapentin?** Gabapentin is a medication used to treat chronic nerve pain and, less commonly, to help control seizures. It is also frequently used to reduce fear and anxiety before stressful events like vet visits. **How to Give This Medication** * Can be given with or without food. * **Never** give the human liquid form (Neurontin) to your dog unless specifically compounded by a veterinary pharmacy, as it contains **xylitol**, an artificial sweetener that is highly toxic and potentially fatal to dogs. **What to Watch For** * The most common side effects are **sleepiness (sedation)** and **wobbliness (ataxia)**. These effects are usually mild and often improve as your pet gets used to the medication. * Contact your veterinarian if your pet seems excessively drowsy or uncoordinated. **Important Notes** * If your pet is taking gabapentin for seizures, **do not stop the medication abruptly**, as this can trigger severe withdrawal seizures. Always consult your vet before changing the dose.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Ancillary therapy of refractory seizures
- Ancillary therapy of refractory seizures
- Ancillary therapy of refractory seizures
- Analgesic
- Adjunctive treatment of chronic or cancer pain
- Adjunctive analgesia associated with neuropathic pain
- Analgesic
- Analgesic
- Adjunctive seizure therapy / Chronic pain
- Ancillary therapy of refractory seizures
- Ancillary therapy of refractory seizures
- Ancillary therapy of refractory seizures
- Ancillary therapy of refractory seizures
給藥方式
可能的副作用
- Sedation
- Ataxia
- Dizziness (humans)
- Somnolence
- Peripheral edema (humans)
- Withdrawal-precipitated seizures (if abruptly discontinued)
- Increased rate of pancreatic adenocarcinoma (noted in male rats)
- Mild sedation
- False-positive urinary protein tests (reported in humans)
- Hepatic toxicity (rare, reported in humans)
注意事項與禁忌
- Hypersensitivity to gabapentin
- Use of xylitol-containing human oral solutions in dogs
- Oral solutions containing xylitol (highly toxic to dogs)
- > **WARNING**: Commercially available human oral solutions (e.g., Neurontin) often contain **xylitol** (up to 300 mg/mL), which is highly toxic to dogs, causing severe hypoglycemia and hepatotoxicity. Avoid use in dogs. * **Renal Insufficiency**: Eliminated primarily via the kidneys. Use with caution and consider dosage adjustments in patients with renal impairment. Dogs partially metabolize the drug (30-40%), so mild to moderate renal dysfunction may not require adjustment. * **Withdrawal**: Abrupt discontinuation can lead to withdrawal-precipitated seizures. Taper the dose gradually when discontinuing, especially in epileptic patients. * **Laboratory Alterations**: May cause false-positive urinary protein readings on Ames N-Multistix SG dipstick tests. Use a sulfosalicylic acid precipitation test instead.
藥物相互作用
- Antacids: Oral antacids given concurrently may decrease oral bioavailability of gabapentin by 20%; separate doses by at least 2 hours.
- Hydrocodone: Co-administration may increase gabapentin AUC and efficacy/adverse effects. Gabapentin may reduce hydrocodone AUC, potentially reducing its effectiveness.
- Morphine: May increase gabapentin levels.
- Antacids (containing aluminium and magnesium): Reduced absorption of gabapentin from the GI tract. Administer gabapentin at least 2 hours after antacids.
- Cimetidine: Reduced renal clearance of gabapentin (not considered clinically important).
常見問題
Gabapentin用於寵物有甚麼用途？
**What is Gabapentin?** Gabapentin is a medication used to treat chronic nerve pain and, less commonly, to help control seizures. It is also frequently used to reduce fear and anxiety before stressful events like vet visits. **How to Give This Medication** * Can be given with or without food. * **Never** give the human liquid form (Neurontin) to your dog unless specifically compounded by a veterinary pharmacy, as it contains **xylitol**, an artificial sweetener that is highly toxic and potentially fatal to dogs. **What to Watch For** * The most common side effects are **sleepiness (sedation)** and **wobbliness (ataxia)**. These effects are usually mild and often improve as your pet gets used to the medication. * Contact your veterinarian if your pet seems excessively drowsy or uncoordinated. **Important Notes** * If your pet is taking gabapentin for seizures, **do not stop the medication abruptly**, as this can trigger severe withdrawal seizures. Always consult your vet before changing the dose.
Gabapentin對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。