Trilostane
別名: Vetoryl, Modrastane, Desopan, Modrenal
Trilostane is a highly effective medication for managing Cushing's disease, but it requires careful handling and monitoring. **Handling Precautions:** * **Keep out of reach of children and pets.** * **Pregnancy Warning:** Women who are pregnant or trying to conceive should **NOT** handle these capsules, as the drug can affect human pregnancies. * Wash your hands thoroughly after handling the medication. * Do not open, empty, or attempt to divide the capsules. **Administration:** * Give the medication exactly as prescribed, ideally **with food** to enhance absorption. * Understand that this medication is a **treatment, not a cure**. Your pet will likely need this medication for the rest of their life. **What to Watch For:** * During the first few days, mild lethargy or a decrease in appetite can occur as your pet's body adjusts to lower steroid levels. * **STOP the medication and contact your veterinarian immediately** if your pet experiences severe lethargy, vomiting, diarrhea, collapse, or completely stops eating. These can be signs that the cortisol levels have dropped too low (an Addisonian crisis).
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Hyperadrenocorticism
- Hyperadrenocorticism
- Hyperadrenocorticism
- Equine Cushing's syndrome
- Hyperadrenocorticism (HAC) - Label Dose
- Hyperadrenocorticism (HAC) - Alternative Protocol
- Hyperadrenocorticism (HAC) - Low Dose Protocol
- Alopecia X (Alaskan Malamutes)
- Alopecia X (Miniature poodles and Pomeranians)
- Hyperadrenocorticism
給藥方式
可能的副作用
- Lethargy
- Inappetence
- Vomiting
- Diarrhea
- Mild electrolyte abnormalities (hyponatremia, hyperkalemia)
- Iatrogenic hypoadrenocorticism (Addisonian crisis)
- Adrenal necrosis (rare but potentially fatal)
- Mild gastrointestinal signs
- Mild increases in serum potassium, bilirubin, and calcium
- Clinical hypoadrenocorticism (Addisonian crisis)
- Adrenal necrosis
- Adrenal hyperplasia (with prolonged treatment)
- Prolonged adrenal suppression after drug withdrawal
注意事項與禁忌
- Hypersensitivity to trilostane
- Pregnancy (reduces progesterone synthesis)
- Use with caution in patients with renal impairment
- Use with caution in patients with hepatic impairment
- Renal insufficiency
- Hepatic insufficiency
- Trilostane is contraindicated in pregnant dogs and should be used with caution in lactating animals. It should be used cautiously in patients with pre-existing renal or hepatic impairment. **Important:** Trilostane does not shrink adrenal tumors; adrenal glands may actually increase in size during therapy due to loss of negative feedback. **Human Safety Warning:** Trilostane is an FDA Category X drug (contraindicated in pregnancy). Pregnant women or women trying to conceive must **not** handle the capsules.
藥物相互作用
- ACE Inhibitors (e.g., benazepril, enalapril): Could increase risk for hyperkalemia
- Aminoglutethimide: May potentiate the effects of trilostane and lead to hypoadrenocorticism
- Ketoconazole: May potentiate the effects of trilostane and lead to hypoadrenocorticism
- Mitotane: May potentiate the effects of trilostane and lead to hypoadrenocorticism
- Potassium-sparing diuretics (e.g., spironolactone): Could increase risk for hyperkalemia
- Potassium supplements / High potassium foods: Could increase risk for hyperkalemia
- Itraconazole: Concurrent suppression of adrenal function
常見問題
Trilostane用於寵物有甚麼用途？
Trilostane is a highly effective medication for managing Cushing's disease, but it requires careful handling and monitoring. **Handling Precautions:** * **Keep out of reach of children and pets.** * **Pregnancy Warning:** Women who are pregnant or trying to conceive should **NOT** handle these capsules, as the drug can affect human pregnancies. * Wash your hands thoroughly after handling the medication. * Do not open, empty, or attempt to divide the capsules. **Administration:** * Give the medication exactly as prescribed, ideally **with food** to enhance absorption. * Understand that this medication is a **treatment, not a cure**. Your pet will likely need this medication for the rest of their life. **What to Watch For:** * During the first few days, mild lethargy or a decrease in appetite can occur as your pet's body adjusts to lower steroid levels. * **STOP the medication and contact your veterinarian immediately** if your pet experiences severe lethargy, vomiting, diarrhea, collapse, or completely stops eating. These can be signs that the cortisol levels have dropped too low (an Addisonian crisis).
Trilostane對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。