Metyrapone
別名: Metopirone
> **Important**: This medication is used to lower the amount of cortisol (stress hormone) your cat's body produces. Because it often needs to be custom-made (compounded) for your cat's specific size, follow the pharmacy's storage instructions carefully. * **Administration**: Give this medication with food to reduce the chance of stomach upset and vomiting. * **Diabetic Cats**: If your cat is also receiving insulin, watch them very closely. As this drug works, your cat's need for insulin may drop dramatically, putting them at risk for low blood sugar (hypoglycemia). Watch for weakness, wobbliness, or seizures. * **When to Call the Vet**: Contact your veterinarian **immediately** if your cat stops eating, seems unusually weak or lethargic, vomits, has diarrhea, or shows changes in drinking or urination. These could be signs that their cortisol levels have dropped too low.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Hyperadrenocorticism
給藥方式
可能的副作用
- Nausea
- Vomiting
- Abdominal pain
- Headache (reported in humans)
- Dizziness (reported in humans)
- Sedation (reported in humans)
- Allergic rash (reported in humans)
- Bone marrow depression (rare)
注意事項與禁忌
- Known hypersensitivity to metyrapone
- Primary adrenal cortical insufficiency (Addison's disease)
- > **Diabetic Patients**: Use with extreme caution and enhanced monitoring in cats with concurrent diabetes mellitus. As cortisol levels drop, insulin resistance resolves, and **hypoglycemia can develop rapidly** if insulin doses are not adjusted. * **Pregnancy**: FDA Category C. Use in pregnant queens only if clearly needed. Fetal pituitary response to the enzymatic block has been detected in humans. * **Lactation**: Safety is unknown; use with caution. * **Laboratory Interference**: May interfere with diagnostic tests. Antidepressants, antithyroid drugs, phenothiazines, barbiturates, and exogenous hormones can alter metyrapone test results.
藥物相互作用
- Acetaminophen: Increased risk for acetaminophen toxicity. Note: Acetaminophen is strictly contraindicated in cats due to fatal methemoglobinemia and hepatotoxicity.
- Corticosteroids: Decreases the efficacy of metyrapone by suppressing ACTH and interfering with the diagnostic or therapeutic intent.
常見問題
Metyrapone用於寵物有甚麼用途？
> **Important**: This medication is used to lower the amount of cortisol (stress hormone) your cat's body produces. Because it often needs to be custom-made (compounded) for your cat's specific size, follow the pharmacy's storage instructions carefully. * **Administration**: Give this medication with food to reduce the chance of stomach upset and vomiting. * **Diabetic Cats**: If your cat is also receiving insulin, watch them very closely. As this drug works, your cat's need for insulin may drop dramatically, putting them at risk for low blood sugar (hypoglycemia). Watch for weakness, wobbliness, or seizures. * **When to Call the Vet**: Contact your veterinarian **immediately** if your cat stops eating, seems unusually weak or lethargic, vomits, has diarrhea, or shows changes in drinking or urination. These could be signs that their cortisol levels have dropped too low.
Metyrapone對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。