메티라폰

용도

• Hyperadrenocorticism

투여 방법

가능한 부작용

• Nausea
• Vomiting
• Abdominal pain
• Headache (reported in humans)
• Dizziness (reported in humans)
• Sedation (reported in humans)
• Allergic rash (reported in humans)
• Bone marrow depression (rare)

주의사항 및 금기

• Known hypersensitivity to metyrapone
• Primary adrenal cortical insufficiency (Addison's disease)
• > **Diabetic Patients**: Use with extreme caution and enhanced monitoring in cats with concurrent diabetes mellitus. As cortisol levels drop, insulin resistance resolves, and **hypoglycemia can develop rapidly** if insulin doses are not adjusted. * **Pregnancy**: FDA Category C. Use in pregnant queens only if clearly needed. Fetal pituitary response to the enzymatic block has been detected in humans. * **Lactation**: Safety is unknown; use with caution. * **Laboratory Interference**: May interfere with diagnostic tests. Antidepressants, antithyroid drugs, phenothiazines, barbiturates, and exogenous hormones can alter metyrapone test results.

약물 상호작용

• Acetaminophen: Increased risk for acetaminophen toxicity. Note: Acetaminophen is strictly contraindicated in cats due to fatal methemoglobinemia and hepatotoxicity.
• Corticosteroids: Decreases the efficacy of metyrapone by suppressing ACTH and interfering with the diagnostic or therapeutic intent.

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