美替拉酮

用途

• Hyperadrenocorticism

給藥方式

可能的副作用

• Nausea
• Vomiting
• Abdominal pain
• Headache (reported in humans)
• Dizziness (reported in humans)
• Sedation (reported in humans)
• Allergic rash (reported in humans)
• Bone marrow depression (rare)

注意事項與禁忌

• Known hypersensitivity to metyrapone
• Primary adrenal cortical insufficiency (Addison's disease)
• > **Diabetic Patients**: Use with extreme caution and enhanced monitoring in cats with concurrent diabetes mellitus. As cortisol levels drop, insulin resistance resolves, and **hypoglycemia can develop rapidly** if insulin doses are not adjusted. * **Pregnancy**: FDA Category C. Use in pregnant queens only if clearly needed. Fetal pituitary response to the enzymatic block has been detected in humans. * **Lactation**: Safety is unknown; use with caution. * **Laboratory Interference**: May interfere with diagnostic tests. Antidepressants, antithyroid drugs, phenothiazines, barbiturates, and exogenous hormones can alter metyrapone test results.

藥物相互作用

• Acetaminophen: Increased risk for acetaminophen toxicity. Note: Acetaminophen is strictly contraindicated in cats due to fatal methemoglobinemia and hepatotoxicity.
• Corticosteroids: Decreases the efficacy of metyrapone by suppressing ACTH and interfering with the diagnostic or therapeutic intent.

常見問題