Acetylcysteine
Còn gọi là: Mucomyst, Acetadote, NAC, ACC, Ilube, Parvolex, Fluimucil
> **Emergency Use:** Acetylcysteine is most commonly used in emergency, clinically supervised settings to treat life-threatening poisonings (such as Tylenol/acetaminophen ingestion). * **Taste and Odor:** The oral liquid formulation has a very strong, unpleasant odor resembling rotten eggs (sulfur) and tastes very bad. Your pet will likely resist taking it. In the hospital, it is often given through a feeding tube or mixed with strong flavorings to ensure the full dose is received. * **Side Effects:** The most common side effect is nausea or vomiting. If your pet vomits shortly after receiving an oral dose, contact your veterinarian immediately, as the dose may need to be repeated. * **Monitoring:** Your pet will require close monitoring, including frequent blood tests, to ensure the liver is recovering and the toxin is being cleared from the body.
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
Veterinary professional? See the full dosing-by-species reference on VetSheet →
What it is used for
- Acetaminophen toxicity
- Acetaminophen toxicity
- Acetaminophen toxicity
- Phenol toxicity
- Hepatotoxicity secondary to xylitol poisoning
- Degenerative myelopathy (anecdotal)
- Mucolytic
- Paracetamol poisoning
- KCS
- Acetaminophen toxicity
- Phenol toxicity
- Adjunctive treatment of hepatic lipidosis
- Mucolytic
- Paracetamol poisoning
- KCS
- To help break up chondroids in the guttural pouch
- Meconium impaction in neonatal foals
- Meconium impaction in neonatal foals
How it is given
Possible side effects
- Nausea and vomiting (especially with oral administration due to poor palatability)
- Urticaria (rare)
- Bronchospasm, chest tightness, and bronchial/tracheal irritation (when inhaled)
- Blood pressure changes and allergic reactions (reported with IV boluses in humans)
Cautions & contraindications
- Hypersensitivity to the drug (specifically for pulmonary indications)
- Use with caution in animals with pre-existing bronchospastic diseases (e.g., feline asthma) when administering via the pulmonary route, as it may trigger bronchospasm. Oral administration can be challenging due to the extremely foul taste and odor (sulfur/rotten eggs); administration via a gastric or duodenal tube is often necessary. If using the inhalation solution for intravenous administration, it is highly recommended to use a 0.2-micron in-line filter. Use caution in nursing dams as it is unknown if the drug enters milk.
Drug interactions
- Activated Charcoal: May adsorb orally administered acetylcysteine, potentially reducing its systemic absorption and efficacy. A 2-3 hour wait between charcoal and oral acetylcysteine is recommended, or acetylcysteine should be given intravenously.
Câu hỏi thường gặp
What is Acetylcysteine used for in pets?
> Emergency Use: Acetylcysteine is most commonly used in emergency, clinically supervised settings to treat life-threatening poisonings (such as Tylenol/acetaminophen ingestion). • Taste and Odor: The oral liquid formulation has a very strong, unpleasant odor resembling rotten eggs (sulfur) and tastes very bad. Your pet will likely resist taking it. In the hospital, it is often given through a feeding tube or mixed with strong flavorings to ensure the full dose is received. • Side Effects: The most common side effect is nausea or vomiting. If your pet vomits shortly after receiving an oral dose, contact your veterinarian immediately, as the dose may need to be repeated. • Monitoring: Your pet will require close monitoring, including frequent blood tests, to ensure the liver is recovering and the toxin is being cleared from the body.
Is Acetylcysteine safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
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