온단세트론

용도

• Empiric dose
• Anti-emetic for intractable vomiting
• Antiemetic for adjunctive treatment of severe pancreatitis
• All uses (nausea and vomiting)
• All uses (nausea and vomiting)
• Severe vomiting (including parvovirus or pancreatitis)
• Chemotherapy-related vomiting
• Adjunctive therapy of acute diarrhea
• Antiemetic
• Antiemetic for adjunctive treatment of uremia
• All uses (nausea and vomiting)
• All uses (nausea and vomiting)

투여 방법

가능한 부작용

• Constipation
• Sedation
• Extrapyramidal clinical signs (head shaking)
• Arrhythmias
• Hypotension
• Headaches (reported in humans)
• Alterations in liver enzymes
• Hypersensitivity reactions (rare)

주의사항 및 금기

• Hypersensitivity to ondansetron or other 5-HT3 antagonists
• Concurrent use with apomorphine (due to risk of severe hypotension)
• Intestinal obstruction
• Ondansetron may mask ileus or gastric distention; it should not be used in place of nasogastric suction. Use with caution in patients with hepatic dysfunction as the half-life may be prolonged. Caution is advised when administering to dogs with the MDR1/ABCB1 mutation, as it is a known P-glycoprotein substrate in humans. Exercise caution in nursing patients as it is excreted in maternal milk.

약물 상호작용

• Apomorphine: Severe hypotension reported in humans; concurrent use is contraindicated.
• Drugs affecting QTc interval (e.g., amiodarone, cisapride, halothane, isoflurane, sotalol): Theoretically may have additive effects on QTc interval, potentially resulting in serious arrhythmias.
• Tramadol: May reduce the efficacy of both drugs (human data); veterinary significance is unknown.

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