Ondansetron
別名: Zofran, Setofilm
Ondansetron is a potent anti-nausea medication often used when other common medications have failed, or for severe conditions like parvovirus, pancreatitis, or during chemotherapy. * **Administration**: Can be given with or without food. If your pet vomits shortly after taking the pill, contact your veterinarian before giving another dose. * **Orally Disintegrating Tablets (ODT)**: If you are prescribed the "melting" tablets, handle them with dry hands. Do not push the tablet through the foil backing; instead, peel the foil back to remove the tablet. Place it gently in your pet's mouth where it will dissolve quickly. * **Side Effects**: Generally very well tolerated. Mild sleepiness or constipation can occasionally occur. Contact your vet if you notice unusual head shaking or extreme lethargy. * **Storage**: Keep out of reach of children and other pets. Store at room temperature away from light and moisture.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Empiric dose
- Anti-emetic for intractable vomiting
- Antiemetic for adjunctive treatment of severe pancreatitis
- All uses (nausea and vomiting)
- All uses (nausea and vomiting)
- Severe vomiting (including parvovirus or pancreatitis)
- Chemotherapy-related vomiting
- Adjunctive therapy of acute diarrhea
- Antiemetic
- Antiemetic for adjunctive treatment of uremia
- All uses (nausea and vomiting)
- All uses (nausea and vomiting)
給藥方式
可能的副作用
- Constipation
- Sedation
- Extrapyramidal clinical signs (head shaking)
- Arrhythmias
- Hypotension
- Headaches (reported in humans)
- Alterations in liver enzymes
- Hypersensitivity reactions (rare)
注意事項與禁忌
- Hypersensitivity to ondansetron or other 5-HT3 antagonists
- Concurrent use with apomorphine (due to risk of severe hypotension)
- Intestinal obstruction
- Ondansetron may mask ileus or gastric distention; it should not be used in place of nasogastric suction. Use with caution in patients with hepatic dysfunction as the half-life may be prolonged. Caution is advised when administering to dogs with the MDR1/ABCB1 mutation, as it is a known P-glycoprotein substrate in humans. Exercise caution in nursing patients as it is excreted in maternal milk.
藥物相互作用
- Apomorphine: Severe hypotension reported in humans; concurrent use is contraindicated.
- Drugs affecting QTc interval (e.g., amiodarone, cisapride, halothane, isoflurane, sotalol): Theoretically may have additive effects on QTc interval, potentially resulting in serious arrhythmias.
- Tramadol: May reduce the efficacy of both drugs (human data); veterinary significance is unknown.
常見問題
Ondansetron用於寵物有甚麼用途？
Ondansetron is a potent anti-nausea medication often used when other common medications have failed, or for severe conditions like parvovirus, pancreatitis, or during chemotherapy. * **Administration**: Can be given with or without food. If your pet vomits shortly after taking the pill, contact your veterinarian before giving another dose. * **Orally Disintegrating Tablets (ODT)**: If you are prescribed the "melting" tablets, handle them with dry hands. Do not push the tablet through the foil backing; instead, peel the foil back to remove the tablet. Place it gently in your pet's mouth where it will dissolve quickly. * **Side Effects**: Generally very well tolerated. Mild sleepiness or constipation can occasionally occur. Contact your vet if you notice unusual head shaking or extreme lethargy. * **Storage**: Keep out of reach of children and other pets. Store at room temperature away from light and moisture.
Ondansetron對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。