에티드론산 이나트륨

용도

• For severe hypercalcemia associated with neoplastic disease
• For severe hypercalcemia associated with neoplastic disease

투여 방법

가능한 부작용

• Diarrhea
• Nausea (with higher oral doses)
• Bone pain/tenderness
• Increases in serum creatinine
• 'Frozen bone' syndrome in dogs (weakened bones and fractures due to inhibited bone remodeling)

주의사항 및 금기

• Severe renal function impairment (serum creatinine >5 mg/dL)
• Risk vs. benefit should be carefully considered in patients with **bone fractures** (delays healing), **enterocolitis** (higher risk of diarrhea), **cardiac failure** (especially with parenteral etidronate as patients may not tolerate the extra fluid load), or those with **moderate renal function impairment** (serum creatinines 2.5-5 mg/dL). > **Warning**: Do not confuse etidronate with etretinate or etomidate. Safety during pregnancy has not been established (FDA Category C). It is unknown if the drug enters milk.

약물 상호작용

• Antacids, dairy products, mineral supplements (iron, magnesium, calcium, aluminum): Absorption of oral etidronate may be inhibited; separate etidronate doses from these substances by at least two hours.

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