エチドロン酸二ナトリウム

使用用途

• For severe hypercalcemia associated with neoplastic disease
• For severe hypercalcemia associated with neoplastic disease

投与方法

考えられる副作用

• Diarrhea
• Nausea (with higher oral doses)
• Bone pain/tenderness
• Increases in serum creatinine
• 'Frozen bone' syndrome in dogs (weakened bones and fractures due to inhibited bone remodeling)

注意事項と禁忌

• Severe renal function impairment (serum creatinine >5 mg/dL)
• Risk vs. benefit should be carefully considered in patients with **bone fractures** (delays healing), **enterocolitis** (higher risk of diarrhea), **cardiac failure** (especially with parenteral etidronate as patients may not tolerate the extra fluid load), or those with **moderate renal function impairment** (serum creatinines 2.5-5 mg/dL). > **Warning**: Do not confuse etidronate with etretinate or etomidate. Safety during pregnancy has not been established (FDA Category C). It is unknown if the drug enters milk.

薬物相互作用

• Antacids, dairy products, mineral supplements (iron, magnesium, calcium, aluminum): Absorption of oral etidronate may be inhibited; separate etidronate doses from these substances by at least two hours.

よくある質問