プラゾシン

使用用途

• Decrease urethral resistance
• Decrease urethral resistance
• Functional urethral obstruction
• Urethral spasm
• Reduce urethral tone
• Adjunctive treatment of heart failure
• Hypertension
• Hypertension in a large dog
• Decrease urethral resistance
• Functional urethral obstruction
• Decrease urethral resistance
• Reduce urethral tone

投与方法

考えられる副作用

• Hypotension (including orthostatic hypotension/syncope)
• Lethargy
• Dizziness
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Tachyphylaxis (drug tolerance)
• Hypotension (especially first-dose effect)
• Lethargy / Weakness
• Dizziness / Syncope
• Gastrointestinal upset (vomiting, diarrhea)
• Reflex tachycardia

注意事項と禁忌

• Preexisting hypotensive conditions
• Pre-existing hypotension
• Hypovolemia
• Known hypersensitivity to alpha-blockers
• > **MDR1/ABCB1 Mutation Warning:** Anecdotal reports suggest dogs with the ABCB1 mutation may be overly sensitive to prazosin. Consider alternate drugs or reduce dosage and increase monitoring (especially blood pressure). * Use with caution in patients with **chronic renal failure**. * Use with caution in patients with preexisting hypotensive conditions. * **First-Dose Effect:** Syncope secondary to orthostatic hypotension can occur after the first dose. Monitor closely.

薬物相互作用

• Beta-blocking agents (e.g., propranolol): May enhance the postural hypotensive effects seen after the first dose of prazosin
• Clonidine: May decrease prazosin antihypertensive effects
• Sildenafil (and other PDE inhibitors): May increase risk for hypotension
• Verapamil or Nifedipine: May cause synergistic hypotensive effects when used concomitantly with prazosin
• Amlodipine: Additive hypotensive effects
• ACE Inhibitors (e.g., Benazepril, Enalapril): Increased risk of severe hypotension
• Beta-blockers (e.g., Propranolol): Exacerbation of postural hypotension
• Sildenafil: Profound hypotension

よくある質問