哌唑嗪
別名: Minipress, Hypovase
藥物類別: Alpha-1 Adrenergic Blocker
* **用途：** 此藥物最常用於幫助放鬆泌尿道，使您的寵物更容易排尿（特別是剛從尿道阻塞中恢復的貓咪）。 * **給藥方式：** 請嚴格按照獸醫師的指示給藥。如果可能，請將藥物與食物一起餵食。 * **首劑效應：** 哌唑嗪可能會導致血壓突然下降，特別是在服用第一劑之後。您的寵物可能會出現頭暈、虛弱或嗜睡的現象。初期請避免讓牠們靠近樓梯或高處，以防摔倒。 * **何時應聯繫獸醫師：** 如果寵物的狀況惡化、無法排尿，或者變得過度嗜睡或抑鬱，請立即通知您的獸醫師。
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Decrease urethral resistance
- Decrease urethral resistance
- Functional urethral obstruction
- Urethral spasm
- Reduce urethral tone
- Adjunctive treatment of heart failure
- Hypertension
- Hypertension in a large dog
- Decrease urethral resistance
- Functional urethral obstruction
- Decrease urethral resistance
- Reduce urethral tone
給藥方式
POIV
可能的副作用
- Hypotension (including orthostatic hypotension/syncope)
- Lethargy
- Dizziness
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Tachyphylaxis (drug tolerance)
- Hypotension (especially first-dose effect)
- Lethargy / Weakness
- Dizziness / Syncope
- Gastrointestinal upset (vomiting, diarrhea)
- Reflex tachycardia
注意事項與禁忌
- Preexisting hypotensive conditions
- Pre-existing hypotension
- Hypovolemia
- Known hypersensitivity to alpha-blockers
- > **MDR1/ABCB1 Mutation Warning:** Anecdotal reports suggest dogs with the ABCB1 mutation may be overly sensitive to prazosin. Consider alternate drugs or reduce dosage and increase monitoring (especially blood pressure). * Use with caution in patients with **chronic renal failure**. * Use with caution in patients with preexisting hypotensive conditions. * **First-Dose Effect:** Syncope secondary to orthostatic hypotension can occur after the first dose. Monitor closely.
藥物相互作用
- Beta-blocking agents (e.g., propranolol): May enhance the postural hypotensive effects seen after the first dose of prazosin
- Clonidine: May decrease prazosin antihypertensive effects
- Sildenafil (and other PDE inhibitors): May increase risk for hypotension
- Verapamil or Nifedipine: May cause synergistic hypotensive effects when used concomitantly with prazosin
- Amlodipine: Additive hypotensive effects
- ACE Inhibitors (e.g., Benazepril, Enalapril): Increased risk of severe hypotension
- Beta-blockers (e.g., Propranolol): Exacerbation of postural hypotension
- Sildenafil: Profound hypotension
常見問題
哌唑嗪用於寵物有甚麼用途？
• 用途： 此藥物最常用於幫助放鬆泌尿道，使您的寵物更容易排尿（特別是剛從尿道阻塞中恢復的貓咪）。 • 給藥方式： 請嚴格按照獸醫師的指示給藥。如果可能，請將藥物與食物一起餵食。 • 首劑效應： 哌唑嗪可能會導致血壓突然下降，特別是在服用第一劑之後。您的寵物可能會出現頭暈、虛弱或嗜睡的現象。初期請避免讓牠們靠近樓梯或高處，以防摔倒。 • 何時應聯繫獸醫師： 如果寵物的狀況惡化、無法排尿，或者變得過度嗜睡或抑鬱，請立即通知您的獸醫師。
哌唑嗪對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。