Prazosin
別名: Minipress, Hypovase
* **Purpose:** This medication is most commonly prescribed to help relax the urinary tract, making it easier for your pet to urinate (especially in cats recovering from a urinary blockage). * **Administration:** Give this medication exactly as directed by your veterinarian. If possible, give the medication with food. * **First-Dose Effect:** Prazosin can cause a sudden drop in blood pressure, especially after the first dose. Your pet may appear dizzy, weak, or lethargic. Keep them away from stairs or high places initially to prevent falls. * **When to call the vet:** Notify your veterinarian immediately if your pet's condition deteriorates, if they are unable to urinate, or if they become excessively lethargic or depressed.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Decrease urethral resistance
- Decrease urethral resistance
- Functional urethral obstruction
- Urethral spasm
- Reduce urethral tone
- Adjunctive treatment of heart failure
- Hypertension
- Hypertension in a large dog
- Decrease urethral resistance
- Functional urethral obstruction
- Decrease urethral resistance
- Reduce urethral tone
給藥方式
可能的副作用
- Hypotension (including orthostatic hypotension/syncope)
- Lethargy
- Dizziness
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Tachyphylaxis (drug tolerance)
- Hypotension (especially first-dose effect)
- Lethargy / Weakness
- Dizziness / Syncope
- Gastrointestinal upset (vomiting, diarrhea)
- Reflex tachycardia
注意事項與禁忌
- Preexisting hypotensive conditions
- Pre-existing hypotension
- Hypovolemia
- Known hypersensitivity to alpha-blockers
- > **MDR1/ABCB1 Mutation Warning:** Anecdotal reports suggest dogs with the ABCB1 mutation may be overly sensitive to prazosin. Consider alternate drugs or reduce dosage and increase monitoring (especially blood pressure). * Use with caution in patients with **chronic renal failure**. * Use with caution in patients with preexisting hypotensive conditions. * **First-Dose Effect:** Syncope secondary to orthostatic hypotension can occur after the first dose. Monitor closely.
藥物相互作用
- Beta-blocking agents (e.g., propranolol): May enhance the postural hypotensive effects seen after the first dose of prazosin
- Clonidine: May decrease prazosin antihypertensive effects
- Sildenafil (and other PDE inhibitors): May increase risk for hypotension
- Verapamil or Nifedipine: May cause synergistic hypotensive effects when used concomitantly with prazosin
- Amlodipine: Additive hypotensive effects
- ACE Inhibitors (e.g., Benazepril, Enalapril): Increased risk of severe hypotension
- Beta-blockers (e.g., Propranolol): Exacerbation of postural hypotension
- Sildenafil: Profound hypotension
常見問題
Prazosin用於寵物有甚麼用途？
* **Purpose:** This medication is most commonly prescribed to help relax the urinary tract, making it easier for your pet to urinate (especially in cats recovering from a urinary blockage). * **Administration:** Give this medication exactly as directed by your veterinarian. If possible, give the medication with food. * **First-Dose Effect:** Prazosin can cause a sudden drop in blood pressure, especially after the first dose. Your pet may appear dizzy, weak, or lethargic. Keep them away from stairs or high places initially to prevent falls. * **When to call the vet:** Notify your veterinarian immediately if your pet's condition deteriorates, if they are unable to urinate, or if they become excessively lethargic or depressed.
Prazosin對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。