Glycopyrrolate
Also known as: Robinul, Robinul-V, Robinul Forte
- **Parenteral administration** is best performed by professional staff in a clinical setting where adequate cardiac monitoring is available. - If your pet is receiving **glycopyrrolate tablets** at home, allow free access to water and encourage drinking, as dry mouth is a common side effect. - Monitor for signs of constipation or difficulty urinating, and contact your veterinarian if these occur.
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
What it is used for
- As an adjunct to anesthesia
- For bradyarrhythmias
- Associated with anesthesia
- As a premed
- As a premed
- For treatment of bradyarrhythmias
- As a bronchodilator
- To control muscarinic adverse effects associated with imidocarb therapy
- For prevention of bradycardia and to decrease airway and salivary secretions (Rabbits)
- As adjunct to anesthesia (Rabbits)
- As a preanesthetic (Rodents)
- As a preanesthetic (Rabbits)
- As part of an injectable anesthesia protocol in rabbits
How it is given
Possible side effects
- Dry secretions (xerostomia)
- Initial bradycardia followed by tachycardia
- Decreased gastrointestinal motility (risk of ileus)
- Decreased urinary tract motility
- Mydriasis and cycloplegia
Cautions & contraindications
- Narrow angle glaucoma
- Tachycardias
- Gastrointestinal ileus
- Urinary obstruction
- Hypersensitivity to the drug
- Pregnancy (per some manufacturer labels)
- Use with **extreme caution** in patients with known or suspected GI infections, as decreased GI motility can prolong retention of toxins or causative agents. Use with extreme caution in patients with autonomic neuropathy. Use cautiously in patients with hepatic or renal disease, geriatric or pediatric patients, hyperthyroidism, hypertension, congestive heart failure (CHF), tachyarrhythmias, prostatic hypertrophy, or esophageal reflux. Can produce sinus tachycardia and predispose hypotensive patients to cardiac arrhythmias (including ventricular fibrillation).
Drug interactions
- Amantadine: May enhance the activity or toxicity of glycopyrrolate.
- Antihistamines (e.g., diphenhydramine): May enhance anticholinergic activity or toxicity.
- Meperidine: May enhance anticholinergic activity or toxicity.
- Phenothiazines: May enhance anticholinergic activity or toxicity.
- Tricyclic Antidepressants (e.g., amitriptyline, clomipramine): May enhance anticholinergic activity or toxicity.
- Amitraz: May aggravate signs seen with amitraz toxicity, leading to hypertension and further inhibition of peristalsis.
- Antacids: May decrease PO absorption; give oral glycopyrrolate at least 1 hour prior to oral antacids.
- Corticosteroids (long-term use): May increase intraocular pressure when used concurrently.
- Digoxin (slow-dissolving): May increase serum digoxin levels; use regular digoxin tablets or oral liquid.
- Ketoconazole: Increased gastric pH may decrease GI absorption; administer 2 hours after ketoconazole.
Frequently asked questions
What is Glycopyrrolate used for in pets?
- **Parenteral administration** is best performed by professional staff in a clinical setting where adequate cardiac monitoring is available. - If your pet is receiving **glycopyrrolate tablets** at home, allow free access to water and encourage drinking, as dry mouth is a common side effect. - Monitor for signs of constipation or difficulty urinating, and contact your veterinarian if these occur.
Is Glycopyrrolate safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
This article is for general education and is not a substitute for professional veterinary advice. If your pet is unwell, please consult a veterinarian.
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