Dinoprost Tromethamine
Also known as: Lutalyse, Prostamate, In-Synch, Amtech Prostamate
> **CRITICAL HUMAN SAFETY WARNING**: Pregnant women, asthmatics, or persons with bronchial diseases must handle this product with extreme caution. Any accidental exposure to the skin should be washed off immediately with soap and water. * This medication is used to manage reproductive conditions (such as uterine infections/pyometra) or to terminate an unwanted pregnancy. * **In dogs and cats**, expect to see side effects shortly after the injection (usually within 5 to 15 minutes). These may include panting, drooling, vomiting, diarrhea, urination, and restlessness. * While these side effects can be distressing to watch, they typically pass within 20 to 30 minutes. Keep your pet in a comfortable, easy-to-clean area during this time. * If your pet experiences severe difficulty breathing, extreme lethargy, or if side effects persist, contact your veterinarian immediately.
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
What it is used for
- Estrus synchronization
- Abortifacient (first two months of pregnancy)
- Estrus synchronization
- Pseudopregnancy (hydrometra/mucometra)
- Abortifacient
- Induce parturition
- Treatment of pyometra
- Abortifacient
- Estrus synchronization
- Unobserved (silent) estrus
- Pyometra
- Abortifacient (5-150 days of gestation)
- Abortifacient (After 150 days of gestation)
- Induce parturition
How it is given
Possible side effects
- Dogs/Cats: Abdominal pain, emesis, defecation, urination, pupillary dilation followed by constriction, tachycardias, restlessness, anxiety, fever, hypersalivation, dyspnea, panting. Fatalities are possible (especially in dogs). Cats may exhibit intense grooming and vocalization.
- Cattle: Infection at injection site, salivation, hyperthermia (especially at higher doses).
- Swine: Erythema, pruritus, urination, defecation, slight ataxia, hyperpnea, dyspnea, nesting behavior, abdominal muscle spasms, tail movements, increased vocalization, salivation.
- Horses: Transient decreased body temperature, sweating. Less frequently: increased respiratory and heart rates, ataxia, abdominal pain, lying down.
Cautions & contraindications
- Pregnancy (unless abortion or induced parturition is desired)
- Intravenous (IV) administration
- Animals with bronchoconstrictive respiratory disease (e.g., asthma, 'heaves' in horses)
- Mares with acute or subacute disorders of the vascular system, GI tract, respiratory system, or reproductive tract
- Camelids (associated with acute toxicity and death)
- Relative contraindication: Closed-cervix pyometra
- Extreme caution in elderly (>8 years old) or debilitated animals, or those with severe cardiopulmonary, renal, or hepatic disease
- **HUMAN SAFETY WARNING**: Pregnant women, asthmatics, and women of childbearing age should handle this product with extreme caution. Accidental skin exposure should be washed off immediately with soap and water. **VETERINARY PRECAUTIONS**: * Do **NOT** administer intravenously (IV). * Use with extreme caution in dogs and cats over 8 years of age or those with significant concurrent illness. * Monitor small animals closely for severe cardiorespiratory effects after administration. * Closed-cervix pyometra is considered a relative contraindication due to the risk of uterine rupture from induced contractions.
Drug interactions
- Other oxytocic agents: Activity may be enhanced by dinoprost.
- Progestins: Reduced effect of dinoprost would be expected with concomitant administration.
Frequently asked questions
What is Dinoprost Tromethamine used for in pets?
> **CRITICAL HUMAN SAFETY WARNING**: Pregnant women, asthmatics, or persons with bronchial diseases must handle this product with extreme caution. Any accidental exposure to the skin should be washed off immediately with soap and water. * This medication is used to manage reproductive conditions (such as uterine infections/pyometra) or to terminate an unwanted pregnancy. * **In dogs and cats**, expect to see side effects shortly after the injection (usually within 5 to 15 minutes). These may include panting, drooling, vomiting, diarrhea, urination, and restlessness. * While these side effects can be distressing to watch, they typically pass within 20 to 30 minutes. Keep your pet in a comfortable, easy-to-clean area during this time. * If your pet experiences severe difficulty breathing, extreme lethargy, or if side effects persist, contact your veterinarian immediately.
Is Dinoprost Tromethamine safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
This article is for general education and is not a substitute for professional veterinary advice. If your pet is unwell, please consult a veterinarian.
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