ジノプロストトロメタミン

使用用途

• Estrus synchronization
• Abortifacient (first two months of pregnancy)
• Estrus synchronization
• Pseudopregnancy (hydrometra/mucometra)
• Abortifacient
• Induce parturition
• Treatment of pyometra
• Abortifacient
• Estrus synchronization
• Unobserved (silent) estrus
• Pyometra
• Abortifacient (5-150 days of gestation)
• Abortifacient (After 150 days of gestation)
• Induce parturition
• Difficult to breed mares / Controlling time of estrus
• Luteolysis and to stimulate uterine contractions
• Abortifacient (Prior to 12th day of pregnancy)
• Abortifacient (After 4th month of pregnancy)
• Abortifacient (From day 80-300)
• Estrus synchronization (Two injection method)
• Estrus synchronization (grouping)
• Abortifacient
• Induce parturition
• Treatment of pyometra (open cervix, non-critically ill, ≤6 years old)
• Abortifacient (After day 25 or 30)
• Adjunctive therapy for termination of mid-term pregnancy

投与方法

考えられる副作用

• Dogs/Cats: Abdominal pain, emesis, defecation, urination, pupillary dilation followed by constriction, tachycardias, restlessness, anxiety, fever, hypersalivation, dyspnea, panting. Fatalities are possible (especially in dogs). Cats may exhibit intense grooming and vocalization.
• Cattle: Infection at injection site, salivation, hyperthermia (especially at higher doses).
• Swine: Erythema, pruritus, urination, defecation, slight ataxia, hyperpnea, dyspnea, nesting behavior, abdominal muscle spasms, tail movements, increased vocalization, salivation.
• Horses: Transient decreased body temperature, sweating. Less frequently: increased respiratory and heart rates, ataxia, abdominal pain, lying down.

注意事項と禁忌

• Pregnancy (unless abortion or induced parturition is desired)
• Intravenous (IV) administration
• Animals with bronchoconstrictive respiratory disease (e.g., asthma, 'heaves' in horses)
• Mares with acute or subacute disorders of the vascular system, GI tract, respiratory system, or reproductive tract
• Camelids (associated with acute toxicity and death)
• Relative contraindication: Closed-cervix pyometra
• Extreme caution in elderly (>8 years old) or debilitated animals, or those with severe cardiopulmonary, renal, or hepatic disease
• **HUMAN SAFETY WARNING**: Pregnant women, asthmatics, and women of childbearing age should handle this product with extreme caution. Accidental skin exposure should be washed off immediately with soap and water. **VETERINARY PRECAUTIONS**: * Do **NOT** administer intravenously (IV). * Use with extreme caution in dogs and cats over 8 years of age or those with significant concurrent illness. * Monitor small animals closely for severe cardiorespiratory effects after administration. * Closed-cervix pyometra is considered a relative contraindication due to the risk of uterine rupture from induced contractions.

薬物相互作用

• Other oxytocic agents: Activity may be enhanced by dinoprost.
• Progestins: Reduced effect of dinoprost would be expected with concomitant administration.

よくある質問