Aglepristone
Also known as: Alizin, Alizine
- **Veterinary Administration Only**: Only veterinary professionals should handle and administer this product due to severe risks associated with accidental human injection. - **Pregnancy Termination**: When used for pregnancy termination in the bitch, understand that aglepristone might only be 95% effective when used between days 26-45. - **Vaginal Discharge**: A brown mucoid vaginal discharge can be seen approximately 24 hours before fetal expulsion. - **Side Effects**: Your pet may exhibit lack of appetite, excitement, restlessness or depression, vomiting, or diarrhea after treatment. - **When to Call the Vet**: Contact your veterinarian if your pet exhibits a purulent (pus-like) or hemorrhagic (bloody) discharge after treatment, or if vaginal discharge persists 3 weeks after treatment. - **Pyometra Treatment**: When used for pyometra, there is a substantial risk of treatment failure, and surgical removal of the uterus and ovaries (spay) may ultimately be required.
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
What it is used for
- To terminate pregnancy (up to day 45)
- To induce parturition
- To induce parturition
- As an adjunct to treating pyometra/metritis (preserve fertility)
- For closed cervix pyometra
- For metritis
- For open or closed pyometra
- For pyometra
- Pregnancy termination
- Progesterone-induced acromegaly
- Pyometra
- For treating mammary fibroadenomatous hyperplasia
- For treating mammary fibroadenomatous hyperplasia
How it is given
Possible side effects
- Injection site reactions (pain, edema, skin thickening, ulceration, localized lymph node enlargement)
- Anorexia (25%)
- Excitation (23%)
- Depression (21%)
- Diarrhea (13%)
- Uterine infections (3.4%)
- Vomiting (2%)
- Brown mucoid vaginal discharge (associated with pregnancy termination)
- Mammary gland congestion
Cautions & contraindications
- Known hypersensitivity to aglepristone
- Pregnancy (unless used specifically for pregnancy termination or inducing parturition)
- Hypoadrenocorticism (Addison's disease) or genetic predisposition to it
- Peritonitis (must be ruled out before using for pyometra)
- Caution in patients with poor health, diabetes, or impaired hepatic/renal function
- > **WARNING**: Accidental injection of this product can induce abortion; it should not be administered or handled by pregnant women. Accidental injection can also cause severe pain, intense swelling, and ischemic necrosis that can lead to serious sequelae, including loss of a digit. Seek prompt medical attention if accidentally injected. * **Injection Site Care**: Light massage of the injection site is recommended after administration. Larger dogs should not receive more than 5 mL at any one SC injection site. Administering into the scruff of the neck may help avoid severe injection reactions. * **Pyometra**: When used for pyometra, there is a substantial risk of treatment failure, and ovariohysterectomy may ultimately be required.
Drug interactions
- Progestins (natural or synthetic): Could reduce the efficacy of aglepristone
- Glucocorticoids: Aglepristone could reduce the efficacy of glucocorticoid treatment due to receptor antagonism
- Ketoconazole: May interact with aglepristone (manufacturer warning, likely due to CYP450 enzyme inhibition)
- Itraconazole: May interact with aglepristone (manufacturer warning)
- Erythromycin: May interact with aglepristone (manufacturer warning)
Frequently asked questions
What is Aglepristone used for in pets?
- **Veterinary Administration Only**: Only veterinary professionals should handle and administer this product due to severe risks associated with accidental human injection. - **Pregnancy Termination**: When used for pregnancy termination in the bitch, understand that aglepristone might only be 95% effective when used between days 26-45. - **Vaginal Discharge**: A brown mucoid vaginal discharge can be seen approximately 24 hours before fetal expulsion. - **Side Effects**: Your pet may exhibit lack of appetite, excitement, restlessness or depression, vomiting, or diarrhea after treatment. - **When to Call the Vet**: Contact your veterinarian if your pet exhibits a purulent (pus-like) or hemorrhagic (bloody) discharge after treatment, or if vaginal discharge persists 3 weeks after treatment. - **Pyometra Treatment**: When used for pyometra, there is a substantial risk of treatment failure, and surgical removal of the uterus and ovaries (spay) may ultimately be required.
Is Aglepristone safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
This article is for general education and is not a substitute for professional veterinary advice. If your pet is unwell, please consult a veterinarian.
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