阿格列酮
別名: Alizin, Alizine
藥物類別: Progesterone Receptor Antagonist
- **僅限獸醫施打**：由於意外注射人體會帶來嚴重風險，本產品僅限由獸醫專業人員操作與施打。 - **終止妊娠**：用於母犬終止妊娠時，請了解在交配後第26至45天使用，成功率約為95%。 - **陰道分泌物**：在胎兒排出前約24小時，可能會觀察到棕色黏液性陰道分泌物。 - **副作用**：治療後，您的寵物可能出現食慾不振、興奮、焦躁或抑鬱、嘔吐或腹瀉等症狀。 - **何時應聯繫獸醫**：若治療後出現化膿或出血性分泌物，或陰道分泌物持續超過3週，請立即聯繫您的獸醫師。 - **子宮蓄膿治療**：用於治療子宮蓄膿時，存在相當的治療失敗風險，最終可能仍需進行外科手術（卵巢子宮摘除術/結紮）。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- To terminate pregnancy (up to day 45)
- To induce parturition
- To induce parturition
- As an adjunct to treating pyometra/metritis (preserve fertility)
- For closed cervix pyometra
- For metritis
- For open or closed pyometra
- For pyometra
- Pregnancy termination
- Progesterone-induced acromegaly
- Pyometra
- For treating mammary fibroadenomatous hyperplasia
- For treating mammary fibroadenomatous hyperplasia
給藥方式
SC
可能的副作用
- Injection site reactions (pain, edema, skin thickening, ulceration, localized lymph node enlargement)
- Anorexia (25%)
- Excitation (23%)
- Depression (21%)
- Diarrhea (13%)
- Uterine infections (3.4%)
- Vomiting (2%)
- Brown mucoid vaginal discharge (associated with pregnancy termination)
- Mammary gland congestion
注意事項與禁忌
- Known hypersensitivity to aglepristone
- Pregnancy (unless used specifically for pregnancy termination or inducing parturition)
- Hypoadrenocorticism (Addison's disease) or genetic predisposition to it
- Peritonitis (must be ruled out before using for pyometra)
- Caution in patients with poor health, diabetes, or impaired hepatic/renal function
- > **WARNING**: Accidental injection of this product can induce abortion; it should not be administered or handled by pregnant women. Accidental injection can also cause severe pain, intense swelling, and ischemic necrosis that can lead to serious sequelae, including loss of a digit. Seek prompt medical attention if accidentally injected. * **Injection Site Care**: Light massage of the injection site is recommended after administration. Larger dogs should not receive more than 5 mL at any one SC injection site. Administering into the scruff of the neck may help avoid severe injection reactions. * **Pyometra**: When used for pyometra, there is a substantial risk of treatment failure, and ovariohysterectomy may ultimately be required.
藥物相互作用
- Progestins (natural or synthetic): Could reduce the efficacy of aglepristone
- Glucocorticoids: Aglepristone could reduce the efficacy of glucocorticoid treatment due to receptor antagonism
- Ketoconazole: May interact with aglepristone (manufacturer warning, likely due to CYP450 enzyme inhibition)
- Itraconazole: May interact with aglepristone (manufacturer warning)
- Erythromycin: May interact with aglepristone (manufacturer warning)
常見問題
阿格列酮用於寵物有什麼用途？
- **僅限獸醫施打**：由於意外注射人體會帶來嚴重風險，本產品僅限由獸醫專業人員操作與施打。 - **終止妊娠**：用於母犬終止妊娠時，請了解在交配後第26至45天使用，成功率約為95%。 - **陰道分泌物**：在胎兒排出前約24小時，可能會觀察到棕色黏液性陰道分泌物。 - **副作用**：治療後，您的寵物可能出現食慾不振、興奮、焦躁或抑鬱、嘔吐或腹瀉等症狀。 - **何時應聯繫獸醫**：若治療後出現化膿或出血性分泌物，或陰道分泌物持續超過3週，請立即聯繫您的獸醫師。 - **子宮蓄膿治療**：用於治療子宮蓄膿時，存在相當的治療失敗風險，最終可能仍需進行外科手術（卵巢子宮摘除術/結紮）。
阿格列酮對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。