靜脈注射脂肪乳劑

用途

• Parenteral Nutrition (PN)
• Rescue agent for fat-soluble drug/toxin intoxication
• Parenteral Nutrition (PN)
• Rescue agent for fat-soluble drug/toxin intoxication

給藥方式

可能的副作用

• Sepsis or thrombophlebitis (secondary to IV catheterization)
• Fat overload syndrome (hyperlipidemia, hepatomegaly, icterus, splenomegaly, fat embolism, thrombocytopenia, hemolysis, prolonged clotting times)
• Pulmonary toxicity (temporary)
• GI effects
• Somnolence
• Headache
• Flushing
• Pancreatitis
• Hypercoagulability
• Hypersensitivity

注意事項與禁忌

• Severe egg yolk allergies
• Abnormal fat metabolism
• Premature and low-birth weight infants (human black box warning)
• Blood coagulation disorders
• Pulmonary disease
• Renal impairment
• Severe liver damage
• Patients at high risk for fat emboli
• **Strict aseptic technique** and excellent IV catheter care are imperative to prevent sepsis. When used alone, IFE may be given via a peripheral line; when combined with amino acids/dextrose as Total Parenteral Nutrition (TPN), a dedicated central line is required due to hypertonicity. Use with caution in critically ill animals due to potential immunosuppression, exacerbation of pulmonary pathology, and increased infection rates. Blood samples for diagnostics should be drawn *prior* to administration to avoid severe lipemia artifacts (falsely high hemoglobin, MCH, MCHC, and altered bilirubin).

藥物相互作用

• Lipid Soluble Drugs: IFE may act as a 'lipid sink', reducing the free circulating levels and clinical efficacy of concurrently administered lipophilic medications.

常見問題