Zidovudine
別名: Retrovir, AZT
- **Experimental Therapy**: This medication is considered an 'experimental' or off-label therapy for cats with viral infections. - **Strict Compliance**: It must be administered exactly as prescribed by your veterinarian to maintain efficacy against the virus. - **Mandatory Blood Tests**: Regular veterinary visits for blood tests are absolutely required (often weekly at first) because this drug can cause severe anemia. - **Watch for Side Effects**: Contact your veterinarian immediately if your cat becomes unusually weak, lethargic, develops pale gums, or stops eating.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Adjunctive therapy of FeLV and FIV
- Adjunctive therapy of FeLV and FIV
- FeLV
- FIV encephalopathy
給藥方式
可能的副作用
- Non-regenerative anemia (most common in cats, dose-dependent)
- Reductions in RBCs, PCV, and hemoglobin
- Diarrhea
- Weakness
- Granulocytopenia (reported in humans)
- Gastrointestinal effects
注意事項與禁忌
- Patients with a history of life-threatening hypersensitivity reactions to zidovudine
- > **Bone Marrow Suppression**: Use with extreme caution in patients with pre-existing bone marrow dysfunction. Cats with bone marrow suppression should generally not be treated with zidovudine. * **Organ Dysfunction**: Dosage adjustment may be necessary in cats with renal or hepatic dysfunction. * **Pregnancy**: FDA Category C for use during pregnancy (animal studies show adverse fetal effects, but adequate human studies are lacking). * **Lactation**: Excreted in milk; clinical significance for nursing offspring is unclear.
藥物相互作用
- Azole Antifungals (e.g., ketoconazole): May increase zidovudine levels
- Atovaquone: May increase zidovudine levels
- Doxorubicin: May antagonize each other's effects; avoid concurrent use. Also increases risk of hematologic toxicity.
- Interferon alfa: Increased risk for hematologic and hepatotoxicity
- Probenecid: May increase zidovudine levels
- Myelo-/Cytotoxic Drugs (e.g., chloramphenicol, flucytosine, vincristine, vinblastine): Administered with zidovudine may increase the risk of hematologic toxicity
- Rifampin: May decrease blood levels (AUC) of zidovudine
常見問題
Zidovudine用於寵物有甚麼用途？
- **Experimental Therapy**: This medication is considered an 'experimental' or off-label therapy for cats with viral infections. - **Strict Compliance**: It must be administered exactly as prescribed by your veterinarian to maintain efficacy against the virus. - **Mandatory Blood Tests**: Regular veterinary visits for blood tests are absolutely required (often weekly at first) because this drug can cause severe anemia. - **Watch for Side Effects**: Contact your veterinarian immediately if your cat becomes unusually weak, lethargic, develops pale gums, or stops eating.
Zidovudine對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。