齊多夫定

用途

• Adjunctive therapy of FeLV and FIV
• Adjunctive therapy of FeLV and FIV
• FeLV
• FIV encephalopathy

給藥方式

可能的副作用

• Non-regenerative anemia (most common in cats, dose-dependent)
• Reductions in RBCs, PCV, and hemoglobin
• Diarrhea
• Weakness
• Granulocytopenia (reported in humans)
• Gastrointestinal effects

注意事項與禁忌

• Patients with a history of life-threatening hypersensitivity reactions to zidovudine
• > **Bone Marrow Suppression**: Use with extreme caution in patients with pre-existing bone marrow dysfunction. Cats with bone marrow suppression should generally not be treated with zidovudine. * **Organ Dysfunction**: Dosage adjustment may be necessary in cats with renal or hepatic dysfunction. * **Pregnancy**: FDA Category C for use during pregnancy (animal studies show adverse fetal effects, but adequate human studies are lacking). * **Lactation**: Excreted in milk; clinical significance for nursing offspring is unclear.

藥物相互作用

• Azole Antifungals (e.g., ketoconazole): May increase zidovudine levels
• Atovaquone: May increase zidovudine levels
• Doxorubicin: May antagonize each other's effects; avoid concurrent use. Also increases risk of hematologic toxicity.
• Interferon alfa: Increased risk for hematologic and hepatotoxicity
• Probenecid: May increase zidovudine levels
• Myelo-/Cytotoxic Drugs (e.g., chloramphenicol, flucytosine, vincristine, vinblastine): Administered with zidovudine may increase the risk of hematologic toxicity
• Rifampin: May decrease blood levels (AUC) of zidovudine

常見問題