Sildenafil
別名: Viagra, Revatio, Aphrodil
> **Important**: Sildenafil is often prescribed "off-label" in veterinary medicine to treat high blood pressure in the lungs (pulmonary hypertension). * **What to expect**: You may notice your pet has more energy, less coughing, and fewer fainting spells (syncope). * **Cost**: Because this is a human medication (often known as Viagra® or Revatio®), it can be expensive. Discuss compounding or generic options with your veterinarian if cost is a concern. * **Safety Warning**: **NEVER** give your pet any other heart medications, especially **nitrates** (like nitroglycerin), while they are on sildenafil, as this combination can cause a fatal drop in blood pressure. * **Side Effects**: Watch for redness or flushing on the belly (inguinal area) or stomach upset. Contact your vet if your pet seems dizzy, lethargic, or collapses.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Moderate to severe PH secondary to either left heart disease or primary lung disease
- Pulmonary arterial hypertension
- Pulmonary hypertension
- Pulmonary hypertension documented by Doppler, chronic pulmonary disease, right-sided heart failure (HW disease; congenital)
- Moderate to severe PH secondary to either left heart disease or primary lung disease
- Pulmonary hypertension
- Pulmonary arterial hypertension
給藥方式
可能的副作用
- Cutaneous flushing of the inguinal region
- Gastrointestinal effects (possible)
- Headache, visual disturbances, dyspepsia, nasal congestion, myalgia, priapism, dizziness, and back pain (reported in humans)
- Vomiting
- Dizziness / weakness
- Raised intraocular pressure
- Systemic hypotension (especially if combined with other vasodilators)
注意事項與禁忌
- Concurrent use with organic nitrates
- Known hypersensitivity to sildenafil
- Pulmonary veno-occlusive disease (PVOD)
- Systemic hypotension
- Significant hepatic impairment
- Significant renal impairment
- Bleeding disorders
- Concurrent use of nitrates
- > **WARNING**: Sildenafil should not be used concurrently with nitrates due to the risk of life-threatening hypotension. * Pulmonary vasodilators may significantly worsen the cardiovascular status of patients with pulmonary veno-occlusive disease (PVOD). * Use with **extreme caution** in patients with resting hypotension, fluid depletion, severe left ventricular outflow obstruction, or autonomic dysfunction.
藥物相互作用
- Alpha-adrenergic blockers (e.g., phentolamine, phenothiazines, phenoxybenzamine): May increase hypotensive effects
- Amlodipine: Potential to increase hypotensive effects
- Antihypertensive, hypotensive drugs: Potentially could increase hypotensive effects
- Azole antifungals (ketoconazole, itraconazole): May reduce sildenafil metabolism and increase AUC
- Cimetidine: May reduce sildenafil metabolism and increase AUC
- Erythromycin, Clarithromycin: May reduce sildenafil metabolism and increase AUC
- Heparin: May increase bleeding risks
- Nitrates (e.g., NTG, Isosorbide): Significant potentiation of vasodilatory effects; life-threatening hypotension possible
- Nitroprusside sodium: Significant potentiation of vasodilatory effects; life-threatening hypotension possible
- Phenobarbital: May decrease sildenafil concentrations
- Rifampin: May decrease sildenafil concentrations
常見問題
Sildenafil用於寵物有甚麼用途？
> **Important**: Sildenafil is often prescribed "off-label" in veterinary medicine to treat high blood pressure in the lungs (pulmonary hypertension). * **What to expect**: You may notice your pet has more energy, less coughing, and fewer fainting spells (syncope). * **Cost**: Because this is a human medication (often known as Viagra® or Revatio®), it can be expensive. Discuss compounding or generic options with your veterinarian if cost is a concern. * **Safety Warning**: **NEVER** give your pet any other heart medications, especially **nitrates** (like nitroglycerin), while they are on sildenafil, as this combination can cause a fatal drop in blood pressure. * **Side Effects**: Watch for redness or flushing on the belly (inguinal area) or stomach upset. Contact your vet if your pet seems dizzy, lethargic, or collapses.
Sildenafil對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。