Sildenafil
別名: Viagra, Revatio, Aphrodil
> **Important**: Sildenafil is often prescribed "off-label" in veterinary medicine to treat high blood pressure in the lungs (pulmonary hypertension). * **What to expect**: You may notice your pet has more energy, less coughing, and fewer fainting spells (syncope). * **Cost**: Because this is a human medication (often known as Viagra® or Revatio®), it can be expensive. Discuss compounding or generic options with your veterinarian if cost is a concern. * **Safety Warning**: **NEVER** give your pet any other heart medications, especially **nitrates** (like nitroglycerin), while they are on sildenafil, as this combination can cause a fatal drop in blood pressure. * **Side Effects**: Watch for redness or flushing on the belly (inguinal area) or stomach upset. Contact your vet if your pet seems dizzy, lethargic, or collapses.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Moderate to severe PH secondary to either left heart disease or primary lung disease
- Pulmonary arterial hypertension
- Pulmonary hypertension
- Pulmonary hypertension documented by Doppler, chronic pulmonary disease, right-sided heart failure (HW disease; congenital)
- Moderate to severe PH secondary to either left heart disease or primary lung disease
- Pulmonary hypertension
- Pulmonary arterial hypertension
給藥方式
可能的副作用
- Cutaneous flushing of the inguinal region
- Gastrointestinal effects (possible)
- Headache, visual disturbances, dyspepsia, nasal congestion, myalgia, priapism, dizziness, and back pain (reported in humans)
- Vomiting
- Dizziness / weakness
- Raised intraocular pressure
- Systemic hypotension (especially if combined with other vasodilators)
注意事項與禁忌
- Concurrent use with organic nitrates
- Known hypersensitivity to sildenafil
- Pulmonary veno-occlusive disease (PVOD)
- Systemic hypotension
- Significant hepatic impairment
- Significant renal impairment
- Bleeding disorders
- Concurrent use of nitrates
- > **WARNING**: Sildenafil should not be used concurrently with nitrates due to the risk of life-threatening hypotension. * Pulmonary vasodilators may significantly worsen the cardiovascular status of patients with pulmonary veno-occlusive disease (PVOD). * Use with **extreme caution** in patients with resting hypotension, fluid depletion, severe left ventricular outflow obstruction, or autonomic dysfunction.
藥物相互作用
- Alpha-adrenergic blockers (e.g., phentolamine, phenothiazines, phenoxybenzamine): May increase hypotensive effects
- Amlodipine: Potential to increase hypotensive effects
- Antihypertensive, hypotensive drugs: Potentially could increase hypotensive effects
- Azole antifungals (ketoconazole, itraconazole): May reduce sildenafil metabolism and increase AUC
- Cimetidine: May reduce sildenafil metabolism and increase AUC
- Erythromycin, Clarithromycin: May reduce sildenafil metabolism and increase AUC
- Heparin: May increase bleeding risks
- Nitrates (e.g., NTG, Isosorbide): Significant potentiation of vasodilatory effects; life-threatening hypotension possible
- Nitroprusside sodium: Significant potentiation of vasodilatory effects; life-threatening hypotension possible
- Phenobarbital: May decrease sildenafil concentrations
- Rifampin: May decrease sildenafil concentrations
常見問題
Sildenafil用於寵物有甚麼用途？
> **Important**: Sildenafil is often prescribed "off-label" in veterinary medicine to treat high blood pressure in the lungs (pulmonary hypertension). * **What to expect**: You may notice your pet has more energy, less coughing, and fewer fainting spells (syncope). * **Cost**: Because this is a human medication (often known as Viagra® or Revatio®), it can be expensive. Discuss compounding or generic options with your veterinarian if cost is a concern. * **Safety Warning**: **NEVER** give your pet any other heart medications, especially **nitrates** (like nitroglycerin), while they are on sildenafil, as this combination can cause a fatal drop in blood pressure. * **Side Effects**: Watch for redness or flushing on the belly (inguinal area) or stomach upset. Contact your vet if your pet seems dizzy, lethargic, or collapses.
Sildenafil對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。