西地那非
別名: Viagra, Revatio, Aphrodil
> **重要提示**：西地那非在獸醫學中常以「仿單標示外使用 (off-label)」的方式處方，用於治療肺部的高血壓（肺動脈高壓）。 * **預期效果**：您可能會發現寵物的活力增加、咳嗽減少，且暈厥次數降低。 * **費用**：由於這是人類藥物（常見商品名為 Viagra® 或 Revatio®），費用可能較高。如果預算有限，可與獸醫師討論使用學名藥或調劑藥品。 * **安全警告**：在寵物服用西地那非期間，**絕對不可**給予其他心臟藥物，特別是**硝酸鹽類**（如硝酸甘油），因為這可能導致致命的血壓驟降。 * **副作用**：請留意寵物腹部（鼠蹊部）是否出現發紅或腸胃不適。如果寵物出現頭暈、嗜睡或癱軟，請立即聯繫獸醫師。
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Moderate to severe PH secondary to either left heart disease or primary lung disease
- Pulmonary arterial hypertension
- Pulmonary hypertension
- Pulmonary hypertension documented by Doppler, chronic pulmonary disease, right-sided heart failure (HW disease; congenital)
- Moderate to severe PH secondary to either left heart disease or primary lung disease
- Pulmonary hypertension
- Pulmonary arterial hypertension
給藥方式
可能的副作用
- Cutaneous flushing of the inguinal region
- Gastrointestinal effects (possible)
- Headache, visual disturbances, dyspepsia, nasal congestion, myalgia, priapism, dizziness, and back pain (reported in humans)
- Vomiting
- Dizziness / weakness
- Raised intraocular pressure
- Systemic hypotension (especially if combined with other vasodilators)
注意事項與禁忌
- Concurrent use with organic nitrates
- Known hypersensitivity to sildenafil
- Pulmonary veno-occlusive disease (PVOD)
- Systemic hypotension
- Significant hepatic impairment
- Significant renal impairment
- Bleeding disorders
- Concurrent use of nitrates
- > **WARNING**: Sildenafil should not be used concurrently with nitrates due to the risk of life-threatening hypotension. * Pulmonary vasodilators may significantly worsen the cardiovascular status of patients with pulmonary veno-occlusive disease (PVOD). * Use with **extreme caution** in patients with resting hypotension, fluid depletion, severe left ventricular outflow obstruction, or autonomic dysfunction.
藥物相互作用
- Alpha-adrenergic blockers (e.g., phentolamine, phenothiazines, phenoxybenzamine): May increase hypotensive effects
- Amlodipine: Potential to increase hypotensive effects
- Antihypertensive, hypotensive drugs: Potentially could increase hypotensive effects
- Azole antifungals (ketoconazole, itraconazole): May reduce sildenafil metabolism and increase AUC
- Cimetidine: May reduce sildenafil metabolism and increase AUC
- Erythromycin, Clarithromycin: May reduce sildenafil metabolism and increase AUC
- Heparin: May increase bleeding risks
- Nitrates (e.g., NTG, Isosorbide): Significant potentiation of vasodilatory effects; life-threatening hypotension possible
- Nitroprusside sodium: Significant potentiation of vasodilatory effects; life-threatening hypotension possible
- Phenobarbital: May decrease sildenafil concentrations
- Rifampin: May decrease sildenafil concentrations
- Erythromycin: Increases plasma sildenafil concentration
- Itraconazole: Increases plasma sildenafil concentration
- Alpha-adrenergic blockers: Increased risk of systemic hypotension; should not be started at the same time
- Nitrates: Significantly enhances hypotensive effect; concomitant use must be avoided
常見問題
西地那非用於寵物有甚麼用途？
> 重要提示：西地那非在獸醫學中常以「仿單標示外使用 (off-label)」的方式處方，用於治療肺部的高血壓（肺動脈高壓）。 • 預期效果：您可能會發現寵物的活力增加、咳嗽減少，且暈厥次數降低。 • 費用：由於這是人類藥物（常見商品名為 Viagra® 或 Revatio®），費用可能較高。如果預算有限，可與獸醫師討論使用學名藥或調劑藥品。 • 安全警告：在寵物服用西地那非期間，絕對不可給予其他心臟藥物，特別是硝酸鹽類（如硝酸甘油），因為這可能導致致命的血壓驟降。 • 副作用：請留意寵物腹部（鼠蹊部）是否出現發紅或腸胃不適。如果寵物出現頭暈、嗜睡或癱軟，請立即聯繫獸醫師。
西地那非對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。